专利号:US-8445713-B2 优先权日:2007-10-22 标 题 :Catalyst for the synthesis of organic carbonates, process for preparing the same and application thereof 发明人:WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; WANG XINKUI; WANG JUNWEI; KANG MAOQING 权利人:WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; WANG XINKUI; WANG JUNWEI; KANG MAOQING; BAYER MATERIALSCIENCE AG 摘要:The present invention relates to a catalyst for the synthesis of organic carbonates, the preparation of the catalyst and the application of this catalyst in the synthesis of organic carbonates from reacting urea and hydroxyl group containing compounds. The catalyst provided in this invention is a calcinate of hydrous salt containing rare earth element at a moderate calcining temperature.
专利号:US-5512701-A 优先权日:1995-06-07 标题:Process for the synthesis of vinyl sulfenic acid derivatives 发明人:HOARD DAVID W; LUKE WAYNE D 权利人:LILLY CO ELI 摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.
专利号:US-5746982-A 优先权日:1996-02-29 标题 :Apparatus for automated synthesis of chemical compounds 发明人:SANEII HOSSAIN; BOROOMAND MOHAMMAD R; FERRIELL MICHAEL R 权利人:ADVANCED CHEMTECH INC 摘要:Apparatus for the synthesis of chemical compounds consists of a housing having a top, front, side and rear walls surrounding and enclosing a reaction table. A track on the rear wall of the housing carries a pair of extending arms on each of which is movably mounted a vertically extendible probe for positioning at various locations over the reaction table. At least on control syringe communicates between the probe and containers for system fluids. A programmable controller is provided for control of the syringe and probes. A reaction block on the reaction table consists of a body having an upper portion and a lower portion and an upper and lower surface and a multiplicity of reaction wells for carrying out the synthesis. Each reaction well is closed at its lower end and open to the upper surface. A flushing conduit is located adjacent each of the well and is in fluid communication with the closed lower end of the reaction well. A manifold section is in fluid communication with the flushing conduit for leading fluid into and out of the body responsive to the creation of a pressure differential between the reaction well and the manifold section. The pressure in the reaction well is greater than that in the manifold section during the flushing of the well. A heating and cooling module may be attached to the reaction block for controlling the temperature of the reaction wells.
专利号:US-2012203004-A1 优先权日:2009-08-13 标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors 发明人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA 权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD 摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-3954709-A 优先权日:1973-05-29 标 题:Phenylethyl group containing resins for the synthesis of peptides 发明人:STEWART JOHN M; MATSUEDA GARY R 权利人:UNIV COLORADO 摘要:The phenylethyl group, ##SPC1## n In polymer carriers for the synthesis of peptides and peptide amides, particularly polymer carriers such as styrene-1% divinyl benzene polymers for use in solid phase peptide synthesis. n The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.
参考文献:10.1021/jo200984n 摘要:Viswambharan B, Okimura T, Suzuki S, Okamoto S. Synthesis and Catalytic Properties of 4-Aryl-2,3-dihydro-4H-pyrimido[2,3-b]benzothiazoles for Asymmetric Acyl or Carboxyl Group Transfer Reactions. J. Org. Chem. 2011 Jul 26;76(16):6678–85. doi: 10.1021/jo200984n. 参考文献:10.1107/s160053681101467x 摘要:Bortoluzzi AJ, Souza LB, Joussef AC, Meyer E. Methyl 4-{[6-(4-bromo-phen-yl)-3-oxo-2,3,4,5-tetra-hydro-pyridazin-4-yl]methyl}benzoate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1230–1.