CAS: 1286770-55-5; (R)-N-(3-(3-Amino-2,5-Dimethyl-1,1-Dioxido-5,6-Dihydro-2H-1,2,4-Thiadiazin-5-yl)-4-Fluorophenyl)-5-Fluoropicolinamide
该化合物是一种化学化合物,其结构复杂,包括一个硫氨环,多种氟替代体和一个复合功能组.该化合物具有潜在的药理应用作用,特别是在医药化学领域,它可能展示针对特定目标的生物活动.氟虫的存在可以加强脂性和代谢稳定性,这是药物设计中可取的特性.硫氨会有助于其独特的再活动以及与生物系统的互动.此外,该化合物的立体化学学,如5R配置所示,可能会影响其生物活动,并会与目标蛋白质有密切关系.
- 英文名称(R)-N-(3-(3-Amino-2,5-Dimethyl-1,1-Dioxido-5,6-Dihydro-2H-1,2,4-Thiadiazin-5-yl)-4-Fluorophenyl)-5-Fluoropicolinamide
- 中文名称维罗司他
- IUPAC名称(R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide
- CAS编号1286770-55-5
- MFCD编号:MFCD28963974
- FDA UNII编号:J1I0P6WT7T
- 分子式:C17H17F2N5O3S分子量:409.42
- 产品CID: 448114
- 同类组份化合物CAS2095432-65-6 (TFA)1286770-55-5 (free base)1875153-95-9 (Tosylate)1970144-54-7 (HBr)1897370-45-4 (hydrate)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
合成工艺路线路线简述
📜1-(5-氨基-2-氟苯基)-1-乙酮置于titanium(Iv) Tetraethanolate,正丁基锂,碳酸氢钠,1-丙基磷酸酐,N,N-二异丙基乙胺,三氟乙酸体系中,用 四氢呋喃,2-甲基四氢呋喃,正己烷,水,甲苯,乙腈 用作溶剂,化学反应 1.5H,反应生成维罗司他
参考文献: Processes For The Preparation Of A Bace Inhibitor[fr] Procédés De Préparation D'Inhibiteurs De Bace
标题: Processes For The Preparation Of A Bace Inhibitor[fr] Procédés De Préparation D'Inhibiteurs De Bace
摘要:这项发明提供了一种改进的工艺,用于制备verubecestat(化合物式(i)),一种强效的bace-1和bace-2抑制剂.
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2912110000-甲醛
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Tosat-Bitrián C, Bueso de Barrio JA, Stewart MH, Susumu K, Medintz IL, Díaz SA, Palomo V. Membrane-Targeted Quantum Dot-Based BACE1 Activity Sensors for In Vitro and In Cellulo Assays. ACS Appl Mater Interfaces. 2024 Nov 20;16(46):63186-63194. doi: 10.1021/acsami.4c12560. Epub 2024 Nov 8.
2: Volloch V, Rits-Volloch S. Principles of Design of Clinical Trials for Prevention and Treatment of Alzheimer's Disease and Aging-Associated Cognitive Decline in the ACH2.0 Perspective: Potential Outcomes, Challenges, and Solutions. J Alzheimers Dis Rep. 2023 Aug 28;7(1):921-955. doi: 10.3233/ADR-230037.
3: Xu E, Park S, Calderon J, Cao D, Liang B. In Silico Identification and In Vitro Validation of Repurposed Compounds Targeting the RSV Polymerase. Microorganisms. 2023 Jun 18;11(6):1608. doi: 10.3390/microorganisms11061608.
合成参考文献
摘要:Amii, H., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
参考文献:10.1056/nejmoa1706441
摘要:Egan MF, Kost J, Tariot PN, Aisen PS, Cummings JL, Vellas B, Sur C, Mukai Y, Voss T, Furtek C, Mahoney E, Harper Mozley L, Vandenberghe R, Mo Y, Michelson D. Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease. N Engl J Med. 2018 May 03;378(18):1691–703.
📝 需求与反馈
尽可能描述清楚需求与问题信息
