CAS: 123-46-6; 2-Hydrazinyl-N,N,N-Trimethyl-2-Oxoethanaminium Chloride

该化合物是能够与碳基组体发生反应后形成稳定的氢氮,可通过包括色谱法和光谱测量在内的各种技术对其进行进一步分析;试剂一般是一种黄色至橙色晶状固体,溶于乙醇和丙酮等有机溶剂,但水中溶液较少;其结构结构具有氢氮酸味,对碳基体的再活动至关重要;Girard-T试剂因其选择性和敏感性而特别受到重视,使其成为实验室研究和工业应用中识别含碳基化合物的有用工具;在处理这种试剂时,应注意安全防范措施,因为如浸泡或吸入,这种试剂可能十分危险,应使用适当的个人防护设备.

结构式图片

相似化合物

5787-71-3 55-85-6 539-64-0

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合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇,一水合肼体系中,化学反应生成吉拉尔特试剂 T
    参考文献:羰基化合物的新形式,微量元素提取物和醛类缩醛的化学利用
    标题:羰基化合物的新形式,微量元素提取物和醛类缩醛的化学利用
    摘要:
    Doi:10.1002/hlca.193601901148

    海关参考信息

    专利信息


    专利号:US-9085538-B2
    优先权日:2010-07-26
    标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
    发明人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
    权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
    摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

    专利号:US-3694472-A
    优先权日:1970-05-12
    标题 :Synthesis of pyrethric acid
    发明人:MARTEL JACQUES; BUENDIA JEAN
    权利人:ROUSSEL UCLAF
    摘要:BY REACTING 3,3-DIMETHYL-2-FORMYL-1-CYCLOPROPANECARBOXYLIC (1R, 2R) acid or a salt thereof with methyl propionate under anhydrous basic conditions. A novel process for the preparation of 3,3-dimethyl-2-(2''methoxycarbonyl-trans 1''-propenyl)-1-cyclopropane carboxylic (1R, 2R) acid or d-trans pyrethric (1R,2R) acid of the formula

    专利号:WO-9618592-A1
    优先权日:1994-12-10
    标 题:Resin-bound phosphonium salts and their use in organic synthesis
    发明人:HUGHES IAN
    权利人:SMITHKLINE BEECHAM PLC; HUGHES IAN
    摘要:The invention relates to carrying out organic chemistry on a solid support, and in particular to the use of a phosphonium salt as a linker for solid phase synthesis.

    专利号:WO-2011121091-A1
    优先权日:2010-03-31
    标题:Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
    发明人:KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
    权利人:KRKA D D NOVO MESTO; KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
    摘要:The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.

    专利号:US-2014051854-A1
    优先权日:2010-07-26
    标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

    专利号:US-4950660-A
    优先权日:1987-09-07
    标 题:Beta-lactam compound and process for production thereof
    发明人:ATSUMI KUNIO; YAMAMOTO YUICHI; SAKAGAMI KENJI; NISHIHATA KEN; KONDO SHINICHI
    权利人:MEIJI SEIKA CO
    摘要:The present invention relates to a cephem compound of formula (III) shown in the description. The compound is useful as an intermediate for the synthesis of beta -lactam antibiotics of new class and also to a process for producing the same. The cephem compound (III) is produced by reacting a cephem compound of formula (I) with a nitrogen-containing compound of formula (II) under acid-capturing conditions. The process can be performed easily under mild conditions.
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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Abraham K Badu-Tawiah, Et Al. Reactions Of Microsolvated Organic Compounds At Ambient Surfaces: Droplet Velocity, Charge State, And Solvent Effects. J Am Soc Mass Spectrom. 2012 Jun;23(6):1077-84.
    [参考文献]: Bert Vissers, Et Al. Unique Potentiometric Detection Systems For Hplc Determination Of Some Steroids In Human Urine. J Sep Sci. 2009 Jan;32(2):167-79.
    [参考文献]: D Serban, Et Al. The Participation Of Trimethylammonium In The Mouse Erythrocyte Epitope Recognized By Monoclonal Autoantibodies. Immunol Lett. 1981 Nov;3(5):315-9.
    [参考文献]: David W Johnson, Et Al. A Modified Girard Derivatizing Reagent For Universal Profiling And Trace Analysis Of Aldehydes And Ketones By Electrospray Ionization Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2007;21(18):2926-32.
    [参考文献]: David W Johnson, Et Al. Analysis Of Succinylacetone, As A Girard T Derivative, In Urine And Dried Bloodspots By Flow Injection Electrospray Ionization Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2007;21(1):59-63.

    合成参考文献


    参考文献:10.1002/rcm.654
    摘要:Gouw JW, Burgers PC, Trikoupis MA, Terlouw JK. Derivatization of small oligosaccharides prior to analysis by matrix-assisted laser desorption/ionization using glycidyltrimethylammonium chloride and Girard's reagent T. Rapid Commun Mass Spectrom. 2002;16(10):905–12. doi: 10.1002/rcm.654.
    参考文献:10.1016/j.saa.2006.02.063
    摘要:Mostafa MM. Spectroscopic studies of some thiosemicarbazide compounds derived from Girard's T and P. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2007 Feb;66(2):480–6. doi: 10.1016/j.saa.2006.02.063.
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