CAS: 1168150-46-6; (E)-Methyl 3-(Methoxy(Phenyl)Methylene)-2-Oxoindoline-6-Carboxylate

相似化合物

1168152-07-5 2803478-52-4 1438271-13-6

上下游产品

2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate (E)-1-cholroacetyl-3-(methoxy(phenyl)methylene)-2-indolone-6-methylformate orthobenzoic acid trimethyl ester nintedanib

2-氧化吲哚-6-甲酸甲酯置于乙酸酐,Potassium Hydroxide体系中,用 甲醇,甲苯 用作溶剂,化学反应 10.0H,反应生成Bibf1120中间体
参考文献:吲哚酮化合物或其衍生物及其用途
标题:吲哚酮化合物或其衍生物及其用途
摘要:本发明涉及通式(A)所示的吲哚酮化合物或其衍生物及其用途.本发明所解决的技术问题是提供了吲哚酮化合物或其衍生物及其用途.本发明采用氘取代吲哚酮化合物得到的一类氘富集的吲哚酮化合物,上述吲哚酮化合物,可同时作用于血管生成过程中涉及的3种关键受体家族-血管内皮生长因子受体(Vegfr),成纤维细胞生长因子受体(Fgfr)以及血小板衍生生长因子受体(Pdgfr),抑制血管生成,从而达到治疗癌症的效果,上述氘代吲哚酮化合物或其衍生物作为药物具有高效的优点.

专利信息

专利号:US-11261158-B2
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives
发明人：PIISOLA ANTTI; TOIS JAN
权利人:FERMION OY
摘要:The present disclosure relates to a preparation method of methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate from methyl 2-oxoindoline-6-carboxylate using high reaction temperatures and a reaction solvent enabling azeotropic removal of acetic acid during the reaction.

专利号:CN-111465594-A
优先权日:2017-11-17
标 题 :Synthesis of 2-indolinones known as intermediates for the preparation of nintedanib

专利号:CN-111465594-B
优先权日:2017-11-17
标题:Synthesis of 2-indolinones known as intermediates for the preparation of Nidamibu

专利号:EP-3710427-B1
优先权日:2017-11-17
标题:Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib