CAS: 106375-28-4; ω-Conotoxin Gvia

专利信息

专利号:US-RE39240-E
优先权日:1993-06-29
标题:Conotoxins I
发明人：OLIVERA BALDOMERO M; RIVIER JEAN E F; CRUZ LOURDES J; ABOGADIE FE; HOPKINS CHRIS E; DYKERT JOHN; TORRES JOSEP L
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetyl-choline receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.

专利号:US-5969096-A
优先权日:1998-06-26
标题 :Conotoxin peptides
发明人：SHON KI-JOON; GRAY WILLIAM R; DYKERT JOHN; YOSHIKAMI DOJU; WATKINS MAREN; HILLYARD DAVID R; RIVIER JEAN E F; OLIVERA BALDOMERO M
权利人:SALK INST FOR BIOLOGICAL STUDI; UNIV UTAH RES FOUND
摘要:Substantially pure conotoxin peptides are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular skeletal nAChRs to the exclusion of neuronal nAChRs. The peptides are of such length that they can be made by chemical synthesis, and the preferred peptides have formula: H-His-4Hyp-4Hyp-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-4Hyp-Gly-Cys-Ser-Ser-Ala-Ser-Cys-Cys-Gln-Xaa24-NH2 wherein Xaa24 is Arg or Gly.