CAS: 91319-54-9; 1-(2-Bromoethyl)-2-Fluorobenzene

该化合物是一种有机化合物,其特点是存在氟原子和与苯乙基组相连的溴原子,该化合物的特点是二位用氟原子替换的苯环,以及连接溴原子的乙基链;卤素(氟和溴)的存在有助于其在有机合成中的再活性和潜在应用,特别是在制药和农用化学品开发中.该化合物通常对浅黄色液体无色,在有机溶剂中表现出中度挥发性和溶解性.该化合物的再活性可归因于卤素原子的电益性,使其在各种化学反应中成为有用的中间体,包括核循环生物替代物.在处理该化合物时应采取安全防范措施,因为它的卤化结构可能对健康造成危害.

结构式图片

物理性质

MSDS等安全信息

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ECHA物质C&L通报

上下游产品

CAS号50919-06-7 2-(2-氟苯基)乙醇 | CAS号451-82-1 邻氟苯乙酸 | CAS号584-74-7 邻氟苯乙酸乙酯 | CAS号1643-26-1 3-(2-氟苯基)丙酸

合成工艺路线路线简述

  • 50919-06-7 = 91319-54-9
    反应条件:1.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: Dichloromethane; 0 °C; Overnight,Rt
    标题:Construction Of Chiral 2-Substituted Octahydroindoles From Cyclic Ketones And Nitroolefins Bearing Only One α-Substituent
    作者:Han,Yong; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2015 卷标:357(6) 页码:1136-1142]

    50919-06-7 = 91319-54-9
    反应条件:1.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: Dichloromethane
    标题:The Effect Of Vinyl Esters On The Enantioselectivity Of The Lipase-Catalyzed Transesterification Of Alcohols
    作者:Kawasaki,M.; Et Al
    参考文献:Tetrahedron: Asymmetry 日期:2001 卷标:12(4) 页码:585-596]

    451-82-1 = 91319-54-9
    反应条件:1.1 Reagents: Hydrogen Bromide,Lithium Aluminum Hydride
    标题:Electroreduction Of Organic Compounds. 19. Formation Of Benzoanellated Sulfur Heterocycles By Intramolecular Cathodic Cyclization Of Dithiocarboxylic Esters
    作者:Gade,Thomas; Et Al
    参考文献:Chemische Berichte 日期:1992 卷标:125(1) 页码:127-41]

    451-82-1 = 91319-54-9
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran1.2 Reagents: Hydrochloric Acid Solvents: Water2.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: Dichloromethane
    标题:The Effect Of Vinyl Esters On The Enantioselectivity Of The Lipase-Catalyzed Transesterification Of Alcohols
    作者:Kawasaki,M.; Et Al
    参考文献:Tetrahedron: Asymmetry 日期:2001 卷标:12(4) 页码:585-596]

    = 91319-54-9 [标题:Reaction Conditions
    标题:Rapid Discovery Of Highly Potent And Selective Inhibitors Of Histone Deacetylase 8 Using Click Chemistry To Generate Candidate Libraries
    作者:Suzuki,Takayoshi; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(22) 页码:9562-9575]

    394-46-7 = 91319-54-9 + 405931-46-6
    反应条件:1.1 Reagents: Acetic Acid,Hydrogen Bromide Solvents: Hexane; 2 H,0 °C
    标题:Scalable Anti-Markovnikov Hydrobromination Of Aliphatic And Aromatic Olefins
    作者:Galli,Marzia; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(24) 页码:5622-5626
📜2-氟苯基乙酸乙酯置于lithium Aluminium Tetrahydride,硫酸,氢溴酸体系中,用 乙醚 作为反应溶剂,化学反应 7.0H,反应生成 2-氟苯乙基溴
参考文献:Houghton,Roy P.; Voyle,Martyn; Price,Raymond,Journal Of The Chemical Society. Perkin Transactions I,1984,# 5,P. 925-931
标题:Houghton,Roy P.; Voyle,Martyn; Price,Raymond,Journal Of The Chemical Society. Perkin Transactions I,1984,# 5,P. 925-931

海关参考信息

专利信息


专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

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主要参考文献

[参考文献]: Son T Nguyen, Et Al. Structure-Activity Relationships Of A Novel Pyranopyridine Series Of Gram-Negative Bacterial Efflux Pump Inhibitors. Bioorg Med Chem. 2015 May 1;23(9):2024-34.

合成参考文献


参考文献:10.1016/j.pharep.2019.06.015
摘要:Lee SY, Hsin LW, Su MJ, ChangChien CC, Ku HC. A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia. Pharmacol Rep. 2019 Dec;71(6):1281–8. doi: 10.1016/j.pharep.2019.06.015.
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