CAS: 74130-04-4; Piperidin-4-Yl(P-Tolyl)Methanone
该化合物是一种有机化合物,其结构特征包括一个管状环和一个氯酮功能组;该化合物的特性是连接着管状氮的4-甲基苯基组,其独特的化学特性有其独特性能;一般在室温下是固体,在有机溶剂中可能表现出中等溶解性;管状环的存在表明潜在的生物活动,因为管状衍生物经常因其药理特性而加以探索;该化合物可能参与各种典型的氯酮化学反应,例如核核乐酚添加;该化合物在生物系统中的具体应用和行为将取决于进一步的研究,包括它与受体或酶的互动;安全数据和处理预防措施,如同任何化学物质一样,应当与任何化学物质一起考虑,以确保适当的实验室做法.
上下游产品
CAS号912768-78-6 4-(4-甲基苯甲酰基)哌啶-... | CAS号4395-98-6 4-氰基哌啶 | CAS号39546-32-2 4-哌啶甲酰胺 | CAS号91419-52-2 N-B°C-4-氰基哌啶合成工艺路线路线简述
📜哌啶-4-甲酰胺置于盐酸,氯化亚砜,碘,碳酸氢钠,Magnesium体系中,用 甲醇,乙醚 作为反应溶剂,化学反应 23.0H,反应生成 3-苄氨基丙酸甲酯
参考文献:新的[(芳基)(芳氧基)甲基]哌啶衍生物及相关化合物的合成和结合研究,它们对5-羟色胺(5-Ht)和去甲肾上腺素(ne)转运蛋白具有高亲和力.
标题:新的[(芳基)(芳氧基)甲基]哌啶衍生物及相关化合物的合成和结合研究,它们对5-羟色胺(5-Ht)和去甲肾上腺素(ne)转运蛋白具有高亲和力.
摘要:在针对新型,高效,速效抗抑郁药的广泛搜索计划中,我们制备了一系列具有(芳基)(芳氧基)甲基部分的新化合物,这些化合物直接或通过亚甲基链连接至不同的取代和未取代环(异喹啉,哌嗪,哌啶,四氢吡喃或环戊烷).已评估这些化合物对血清素(5-Ht)转运蛋白(sert)和5-Ht(1A)和5-Ht(2A)受体的亲和力.4-[((芳基)(芳氧基)甲基]哌啶衍生物的外消旋混合物对sert的亲和力值比氟西汀高得多,并导致对5-Ht(1A)和5-Ht(2A)受体的亲和力不足.这些外消旋混合物中的一些被拆分为其对映异构体,并测试与去甲肾上腺素(ne)转运蛋白(net),多巴胺(da)转运蛋白(dat)和alpha(2)受体的结合.这些对映异构体中的几种[(-)-15B,(-)-15J,(-)-15T,(+)-15U]表现出对sert和net具有亲和力的k(i)<25 Nm和a Net / Sert比率<10.化
DOI:10.1021/jm0309349
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2912210000-苯甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-0010565-A1
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI; DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
专利号:US-6992097-B2
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
