CAS: 7199-29-3; 10,11-Dihydro-5H-Dibenzo[a,D][7]Annulene-5-Carboxamide

该化合物是属于类胺的化学化合物,其特征是结构特征,包括循环结构结构,有助于其独特的特性;Cyheptamide以其在药用化学中的潜在应用,特别是药物开发中的潜在应用而著称;该化合物展示了一系列生物活动,其中可能包括抗炎和止痛作用,使其对治疗研究感兴趣;各种溶剂的溶解性和稳定性可以不同,影响其配制和在不同用途中的使用;与许多化学物质一样,安全和处理预防措施必不可少,如果管理不当,可能会带来风险;总的来说,cyctamide是一种具有诱人特性的化合物,值得在实验室和临床环境中进一步调查.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    📜10,11-二氢-5H-二苯并[a,D]环庚烯-5-甲腈置于硫酸体系中,化学反应生成 环庚米特
    参考文献:新的精神药物.v.5-氰基和5-羧酰胺基二苯并(a,D)环庚二烯的衍生物.
    标题:新的精神药物.v.5-氰基和5-羧酰胺基二苯并(a,D)环庚二烯的衍生物.
    摘要:
    DOI:10.1021/jm00339A008

    海关参考信息

    专利信息


    专利号:US-2008194629-A1
    优先权日:2005-05-03
    标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
    发明人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
    权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
    摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    主要参考文献


    1: van Eeken CJ, Birtwhistle RD, Mulder D. Toxicological study of cyheptamide: 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxamide (BS 7029). Arch Int Pharmacodyn Ther. 1970 Nov;188(1):79-85. doi: 10.1002/bmc.1749. Epub 2012 Jan 4.
    5: Jones GL, Amato RJ, Wimbish GH, Peyton GA. Comparison of anticonvulsant potencies of cyheptamide, carbamazepine, and phenytoin. J Pharm Sci. 1981 Jun;70(6):618-20. Epub 2007 Oct 25. doi: 10.1039/c6cc01710j. Spanish.
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