CAS: 623-53-0; Ethyl Methyl Carbonate

相似化合物

920-42-3 56525-42-9 35466-83-2

上下游产品

methanol (ethoxydichloromethyl)sulfenyl chloride chloroformic acid ethyl ester sodium methylatemethoxybenzene Phenetole methanol ethene

乙醇,氯甲酸甲酯置于吡啶体系中,化学反应 48.0H,以52%的收率获得产物碳酸甲乙酯
参考文献:消除热量的机制.第15部分.由于羰基的亲核性增强,碳酸烷基甲基碳酸酯和s-烷基o-甲基碳酸酯的热解速率分布异常
标题:消除热量的机制.第15部分.由于羰基的亲核性增强,碳酸烷基甲基碳酸酯和s-烷基o-甲基碳酸酯的热解速率分布异常
摘要:对于每种化合物,已在50 K的范围内测量了热解消除碳酸乙酯,异丙酯和叔丁基碳酸酯以及碳酸二叔丁酯的速率系数.600 K下的相对速率为1:29.6:2 934:3 526,伯,仲和叔化合物的扩散速率与消除一系列其他酯(包括碳酸烷基苯酯)所得的速率不一致.发现反应性最低的化合物比预期的反应性更高,这可能是由于其过渡态的较高e I特性和碳酸二烷基酯中羰基的高亲核性共同造成的.s-乙基,S-异丙基和s-叔丁基o的热解速率数据-甲基碳酸盐给予在600 K中的相对速率为1:22:1 074的卜吨:Pr我速率比(49:1),因此比镨更大我:Et比率,与所有其他相关抵销一样;这证实了文献结果(显示出相反的结果)是错误的.与羰基亲核性的重要性相比,硫醇乙酸酯和硫代碳酸酯与它们的含氧类似物相比看似异常的相对反应性也与酯热解中过渡态的可变极性的影响相一致,这也解释了硫醇,硫代和二硫代乙酸酯的相对反应性.对于碳酸
DOI:10.1039/p29830000291

专利信息

专利号:WO-2009152051-A1
优先权日:2008-06-12
标题:Synthesis of a macrocyclic hcv protease inhibitor
发明人：WANG PENG
权利人:PHENOMIX CORP; WANG PENG
摘要:The present invention provides a method of synthesis of a macrocyclic compound known as a potent inhibitor of a protease produced by the hepatitis C virus (HCV). Inhibition of the viral protease blocks assembly of mature viral particles in an infected mammalian host. The method of synthesis involves a ring-closing metathesis step using a ruthenium catalyst. Hydrogenation and boronate deprotection provide the HCV protease-inhibitory product.

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:US-8163430-B2
优先权日:2000-01-18
标 题:Synthesis of metal compounds under carbothermal conditions
发明人：BARKER JEREMY; SAIDI YAZID; DONG MING; SWOYER JEFFREY
权利人:BARKER JEREMY; SAIDI YAZID; DONG MING; SWOYER JEFFREY; VALENCE TECHNOLOGY INC
摘要:Active materials of the invention contain at least one alkali metal and at least one other metal capable of being oxidized to a higher oxidation state. Preferred other metals are accordingly selected from the group consisting of transition metals (defined as Groups 4-11 of the periodic table), as well as certain other non-transition metals such as tin, bismuth, and lead. The active materials may be synthesized in single step reactions or in multi-step reactions. In at least one of the steps of the synthesis reaction, reducing carbon is used as a starting material. In one aspect, the reducing carbon is provided by elemental carbon, preferably in particulate form such as graphites, amorphous carbon, carbon blacks and the like. In another aspect, reducing carbon may also be provided by an organic precursor material, or by a mixture of elemental carbon and organic precursor material.

专利号:US-4894385-A
优先权日:1985-01-16
标 题:Imidazole derivatives as inhibitors of TXA2 synthesis
发明人：KAWAMOTO ISAO; ENDO ROKURO; MATSUDA KEIICHI; USHIYAMA SHIGERU; OSHIMA TAKESHI
权利人:SANKYO CO
摘要:Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R 1 , R 2 , R 4 , R 5 , R 6 , X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A 2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.

专利号:US-2014199585-A1
优先权日:2013-01-17
标 题 :Low Symmetry Molecules And Phosphonium Salts, Methods Of Making And Devices Formed There From
发明人：RUPERT BENJAMIN L; BEER LEANNE
权利人:ESIONIC ES INC
摘要:Synthesis of molecules and salts is disclosed having low average symmetry and their use in many applications, including but not limited to: as electrolytes in electronic devices such as memory devices including static, permanent and dynamic random access memory, as electrolytes in energy storage devices such as batteries, electrochemical double layer capacitors (EDLCs) or supercapacitors or ultracapacitors, electrolytic capacitors, as electrolytes in dye-sensitized solar cells (DSSCs), as electrolytes in fuel cells, as a heat transfer medium, high temperature reaction and/or extraction media, among other applications. In particular, synthesis methods and processes to form molecules and salts having low average symmetry using mixed Grignard reagents are disclosed.

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.