CAS: 60835-75-8; 2,3,5,6,8,9,11,12,14,15-Decahydrobenzo[b][1,4,7,10,13,16]Hexaoxacyclooctadecine-18-Carboxylic Acid

该化合物是皇冠醚家族的成员,其特点是能够有选择地结合含有多醚联系的循环结构,该化合物具有18人环的特点,其中包括六乙氧原子,形成一个适合与各种金属离子,特别是碱和碱土金属协调的圆锥体.在苯并峰的副位置上存在一个箱式酸组,可以增强其在极地溶剂中的溶性,也可以参与氢的结合,影响其结合特性.该化合物经常用于超分子化学和分析应用,例如离子选择性电极和提取过程.其形成稳定的电离子复合体的能力使得它在各个领域,包括环境化学和材料科学领域都有价值.此外,4欧元-卡本位18-crownown-6的结构特征允许进行可能的修改,从而能够设计符合特定应用特性的衍生物.

结构式图片

相似化合物

14098-24-9 75460-28-5 68941-06-0

欧盟法规

ECHA物质C&L通报

上下游产品

4'-乙酰苯并-18-冠-6-醚 4'-Acetylbenzo-18-Crown-6 41855-35-0

合成工艺路线路线简述

  • 合成目标产物 2,3-(4-Carboxybenzo)-1,4,7,10,13,16-Hexaoxacyclooctadec-2-Ene 主要起始原料 Benzo-18-Crown-6 And Trifluoroacetic Acid
  • (文献来源)合成步骤主要原料 Benzo-18-Crown-6 和 Trifluoroacetic Acid
📜苯并-18-冠-6-醚,三氟乙酸置于乌洛托品,盐酸体系中,化学反应 26.83H,以70%的收率获得产物4'-羧基苯并-18-冠6-醚
参考文献:Sequential Energy Transfer Followed By Electron Transfer In A Bodipy-bisstyrylbodipy Bound To C60 Triad Via A 'two-Point' Binding Strategy
标题:Sequential Energy Transfer Followed By Electron Transfer In A Bodipy-bisstyrylbodipy Bound To C60 Triad Via A 'two-Point' Binding Strategy
摘要:在一个自组装的,宽带捕获三元体中,展示了逐步能量转移后电子转移发生,导致产生一个电荷分离状态,这类似于光合作用天线反应中心的模拟.
DOI:10.1039/c7Cc08063H

海关参考信息

专利信息


专利号:US-7683025-B2
优先权日:2002-11-14
标 题:Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
发明人:STUPP SAMUEL I; CLAUSSEN RANDAL C; RABATIC BRYAN M
权利人:UNIV NORTHWESTERN
摘要:The present invention provides for bola amphiphiles compositions which have more than one lyophilic (hydrophilic) head group and a hydrophobic (hydrophobic) moiety capable of hydrogen bonding with other bola amphiphiles. These bola amphiphiles are capable of self assembling into micelles. The advantage of these bola amphiphiles is that they may self-assemble into micelles whose lyophilic head groups are located within the core and on the surface of the micelles. The lyophilic environment at the core and on the surface of the micelles may be different and may be controlled by the choice of head group moieties on the bola amphiphiles. The utility of these compositions is that they can be used to load or encapsulate polar drugs, DNA, mineralizable inorganic salts, or other molecules of interest within the polar interior of the micelle. Such compositions may also provide small water-filled ion-conducting channels within their structure suitable for use in micro electromechanical devices, as templates for nanowires or dielectrics, and as chemical sensors.

专利号:US-9073802-B2
优先权日:2010-02-12
标题 :Method for producing 18F-labeled compound and high molecular compound to be used in the method
发明人:TAKAHASHI TAKASHI; TANAKA HIROSHI; NAKADA TSUTOMU
权利人:TAKAHASHI TAKASHI; TANAKA HIROSHI; NAKADA TSUTOMU; TOKYO INST TECH; UNIV NIIGATA
摘要:The present invention aims at solving the problems of conventional methods for producing an 18 F-labeled compound, that is, the problem of purification of a compound in a liquid phase synthesis method and the problem of an insufficient yield due to the reduction of reactivity in a solid phase synthesis method. There is provided a method for producing an 18 F-labeled compound including: allowing a high molecular compound containing a residue of a precursor compound to be labeled and a residue of a phase transfer catalyst in the molecule thereof to react with 18 F − ; and removing the 18 F-labeled compound from the high molecular compound.

专利号:ES-2686136-A1
优先权日:2017-03-29
标题 :SYNTHESIS PROCEDURE OF 9,10-BIS (CHLOROMETHYL) ANTHRACEN (Machine-translation by Google Translate, not legally binding)

专利号:US-2006110437-A1
优先权日:2002-11-14
标 题 :Synthesis and self-assembly of abc triblock bola peptide

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Yokoyama T, Mizuguchi M. Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J Med Chem. 2019 Feb 28;62(4):2076-2082. doi: 10.1021/acs.jmedchem.8b01700. Epub 2019 Feb 8.

合成参考文献


参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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