CAS: 5796-31-6; Ecgonine Hydrochloride
该化合物是一种双环化合物,其特点是独特的an-zabicycly结构,其中包括环状系统中的氮原子.该化合物的特点是一个碳oxylic酸功能组和一个氢氧xyl组,其作为生物活性分子的潜力.在8个位置上的甲基组的存在增加了其性能,影响其与生物目标的相互作用.盐盐的盐形式表明,它经常以更稳定,更易溶解的形式使用,有利于药物的应用.其结构学和化学特征(1R2R,3S,5S)表明,该化合物确定了其原子的空间安排,这可对其生物活动和药理学产生显著影响.
- 英文名称Ecgonine Hydrochloride
- 中文名称芽子碱盐酸盐
- IUPAC名称(1R,2R,3S,5S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid;hydrochloride
- 其它别名1aH,5aH-Tropane-2b-carboxylic acid, 3b-hydroxy-, hydr°Chloride (8CI); 8-Azabicyclo[3.2.1]°Ctane-2-carboxylic acid, 3-hydroxy-8-methyl-,hydr°Chloride, (1R,2R,3S,5S)- (9CI); 8-Azabicyclo[3.2.1]°Ctane-2-carboxylicacid, 3-hydroxy-8-methyl-, hydr°Chloride, [1R-(exo,exo)]-; Ecgoninehydr°Chloride (6CI); (-)-Ecgonine hydr°Chloride; L-Ecgonine hydr°Chloride
- CAS编号5796-31-6
- MFCD编号:MFCD00069267
- EINECS号:689-195-7
- FDA UNII编号:W1Q6UAE4VA
- 分子式:C9H16ClNO3分子量:221.68
- 产品CID: 1554716
- 产品分类有机原料 → 生物碱及其衍生物 → 托烷生物碱
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别3(吸入)
急性毒性 类别3(经皮)
急性毒性 类别3(经口)
皮肤致敏 类别1 - 警示词Danger(危险)
- 危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
H317 |可能引起皮肤过敏反应. - 防范说明P210-P260-P280-P301+P310-P311
- UN编号UN1230 - class 3 - PG 2 - Methanol, solution
- 危险品标志F,T
- 安全声明7-16-36/37-45
- 危险类别码11-23/24/25-39/23/24/25
- WGK Germany3
欧盟法规
C&L通报上下游产品
(-)-c°Caine hydr°Chloride C°Caineecgonine ethyl ester Ecgonine methyl ester hydr°Chloride (1R,2R,3S,5S)-3-Hydroxy-8-methyl-8-aza-bicyclo[3.2.1]°Ctane-2-carboxylic acid 5-benzyloxycarbonyl-pentyl ester (1R,2R,3S,5S)-3-Benzoyloxy-8-methyl-8-aza-bicyclo[3.2.1]°Ctane-2-carboxylic acid 5-carboxy-pentyl ester合成工艺路线路线简述
📜古卡因置于盐酸,水体系中,化学反应 20.0H,以98.42%的收率获得产物芽子碱盐酸盐
参考文献:Method For Preparing Organoboron Derivative Containing Oxygen And Aromatic Ring As Labeled Precursor Of Dopamine Positron Emission Tomography Imaging Agent
标题:Method For Preparing Organoboron Derivative Containing Oxygen And Aromatic Ring As Labeled Precursor Of Dopamine Positron Emission Tomography Imaging Agent
摘要:揭示了一种制备含氧原子和芳香环的有机硼衍生物作为多巴胺正电子发射断层扫描成像剂的标记前体的方法.可卡因的盐酸盐被用作引发剂.含氧原子的有机硼衍生物直接在芳香环上反应生成作为药物物质,并且芳香环直接标记了放射性同位素氟-18(f-18).该方法仅需五个步骤,包括四个步骤用于制备含氧原子和芳香环的有机硼衍生物作为药物物质,以及一步用于直接将有机硼衍生物的芳香环标记为f-18.不仅显著缩短了过程时间,还有效提高了总产率.
海关参考信息
- 2905122000-异丙醇
2905399001-1,3-丙二醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5663345-A
优先权日:1992-12-31
标 题:Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same
发明人：SOMERS LOWELL M; WYNN JAMES E
权利人:ENTROPIN INC
摘要:The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular. disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. The compounds of this invention are conveniently obtained by chemical synthesis. Accordingly, this invention also relates to methods for preparing the benzoylecgonine, ecgonine and ecgonidine derivatives and to pharmaceutical compositions containing these derivatives.
专利号:RU-2134264-C1
优先权日:1994-04-19
标题 :Derivatives of tropan-2-aldoxime, method of their synthesis, pharmaceutical composition and substances for drug production on said, method of treatment of patients with disorder or disease
专利号:RU-2167876-C2
优先权日:1996-02-22
标题:2,3-trans-disubstituted tropan derivative, method of its synthesis, pharmaceutical composition
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Bulletin of Experimental Biology and Medicine, 86(1325), 1978
📝 需求与反馈
尽可能描述清楚需求与问题信息
