Lead Acetate 以 水作为反应溶剂,获得 Lead Acetate,Tetra- 参考文献:铅 (II) 离子和乙酸根离子之间的络合物形成 标题:铅 (II) 离子和乙酸根离子之间的络合物形成 摘要:已在 25°c 下以 3 M (Na)Clo4 作为离子介质检测了铅 (II) 和乙酰根离子之间的复合物形成.平衡常数由电位滴定法确定,此时游离铅浓度 [Pb2+] 是用铅汞合金电极和"Wilhelm"型参考电桥测量的:在每个系列中,分析铅浓度 Cpb2+ 保持恒定,而配体浓度不同.为了避免铅离子水解,向高氯酸铅溶液中加入适量的高氯酸. Doi:10.1038/197283B0
专利号:WO-2004037772-A1 优先权日:2002-10-22 标 题 :Convenient and scalable synthesis of ethyl n-[(2-boc-amino) ethyl] glycinate and its hydrochloride salt 发明人:HUDSON ROBERT H E; VIIRRE RUSSELL D 权利人:UNIV WESTERN ONTARIO; HUDSON ROBERT H E; VIIRRE RUSSELL D 摘要:The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, non-hygroscopic solid that is a convenient form for handling and storage.
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-10973847-B2 优先权日:2017-06-30 标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof 发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.
专利号:US-3947517-A 优先权日:1969-06-12 标题:Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines 发明人:MUXFELDT HANS H; MICHAEL JEFFREY 权利人:RESEARCH CORP 摘要:In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic procedures for obtaining tetracycline precursors are discussed.
专利号:US-6355826-B1 优先权日:1997-09-17 标题:Synthesis of stable nitrile oxide compounds 发明人:PARKER DANE KENTON 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.
专利号:US-5424421-A 优先权日:1990-07-17 标 题:Synthesis of carminic acid and principal intermediates 发明人:TYMAN JOHN H P; FIECCHI ALBERTO 权利人:EUROP COLOUR PLC 摘要:The invention relates to the synthesis of 6-deoxykermesates, 6-deoxykermesic acid, and carminic acid, based on a reaction of a 2-halogenonapthazarin with a bis-trimethylsilyl-diene.
[参考文献]: B H Jennings, Et Al. The Oxidation Of A Steroidal Bromohydrin Revisited. Steroids. 1981 Jan;37(1):7-22. [参考文献]: Barbara Grzeszczyk, Et Al. A Practical Preparation Of The Key Intermediate For Penems And Carbapenems Synthesis. J Antibiot (Tokyo). 2013 Mar;66(3):161-3. [参考文献]: H K Lo, Et Al. Lead Tetraacetate-Thiocarbohydrazide-Silver Proteinate Method For Light Microscopy Of Polysaccharides. Biotech Histochem. 1992 Nov;67(6):372-6. [参考文献]: Hidehito Urata, Et Al. First Chemical Synthesis Of Antioxidative Metabolites Of Sesamin. Chem Pharm Bull (Tokyo). 2008 Nov;56(11):1611-2. [参考文献]: Hiromitsu Takayama, Et Al. Formation Of An Unusual Dimeric Compound By Lead Tetraacetate Oxidation Of A Corynanthe-Type Indole Alkaloid, Mitragynine. Chem Pharm Bull (Tokyo). 2002 Jul;50(7):960-3.
合成参考文献
摘要:Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 843 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要: 摘要:29 CFR 1910.1025 (USDOL); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of November 3, 2009: 摘要:40 CFR 261.24 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of November 2, 2009: https://www.ecfr.gov