CAS: 521-17-5; Androst-5-Ene-3β,17β-Diol

上下游产品

dehydroepiandrosterone ethylmagnesium iodide diethyl ether dehydroepiandrosterone3,17-Dioxo-androsten-5 5-Androsten-3,17-dionΔ5-Androsten-3,17-dion 3β,17β-androst-5-ene diol diacetate (3β,17β)-androst-5-ene-3,17-diol, dipropanoate

📜去氢表雄酮置于dehydrogenase体系中,化学反应生成 雄烯二醇
参考文献:寄生曲霉对脱氢表雄酮的生物转化:Bvmo活性的代谢证据.
标题:寄生曲霉对脱氢表雄酮的生物转化:Bvmo活性的代谢证据.
摘要:由于类固醇及其衍生物的临床应用,其合成研究备受关注.由于具有生物活性,因此特别关注带有d环内酯(如睾丸内酯)的分子.由于曲霉属提供了氧化还原酶的工具箱,因此已被用于进行类固醇生物转化.在这项工作中,描述了使用寄生曲霉的生长细胞来研究脱氢表雄甾酮(dhea)的生物转化,强调了导致d环内酯化产物的代谢步骤.观测到寄生寄生曲霉不仅能够转化标准的拜耳-维利格单加氧酶(bvmo)底物双环[3.2.0] Hept-2-En-6-One,而且还产生了睾丸内酯和同内酯3Beta Dhea的-Hydroxy-17A-Oxa-D-Homoandrost-5-En-17-One.而且,该生物催化剂通过氧化途径降解了可的松的侧链,暗示了bvmo的作用,从而提供了足够的代谢证据,表明寄生葡萄曲霉中存在bvmo活性.此外,由于观测到极好的生物转化率,寄生寄生曲霉是大规模生产甾体来源的基于生物活性内酯的化合物的有前途的候选者.
DOI:10.1016/j.Steroids.2016.03.018

专利信息

专利号:US-2004137081-A1
优先权日:2003-01-13
标题 :Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins
发明人：ROHDEWALD PETER; FERRARI VICTOR
摘要:Sexual wellness or sexual fitness is enhanced over time by administrating on a daily basis a source of proanthocyanidins and a source of arginine. Both sources may be blended into a composition or taken separately from a kit. The source of arginine may be a salt or peptide of L-arginine and aspartic acid such as arginine aspartate. The proanthocyanidins stimulate an endothelial NO-synthase enzyme, which serves as a catalyst for synthesis of the nitric oxide from a substration that is the source of the arginine. A sufficient amount of the nitric oxide is released over time to enhance sexual wellness or sexual fitness. In case of low levels of androgenic hormones in both sexes, the combination may contain as a further ingredient a sex hormone or a sex hormone precursor or a sex hormone stimulant or a sex hormone bioavailability enhancer.

专利号:US-2005171030-A1
优先权日:2000-05-26
标题:Relieving symptoms of erectile dysfunction and attaining sexual wellness and health of the sexual vascular system with proanthocyanidins
发明人：ROHDEWALD PETER; FERRARI VICTOR
摘要:Sexual wellness or sexual fitness is enhanced over time by administrating on a daily basis a source of proanthocyanidins and a source of arginine. Both sources may be blended into a composition or taken separately from a kit. The source of arginine may be a salt or peptide of L-arginine and aspartic acid such as arginine aspartate. The proanthocyanidins stimulate an endothelial NO-synthase enzyme, which serves as a catalyst for synthesis of the nitric oxide from a substration that is the source of the arginine. A sufficient amount of the nitric oxide is released over time to enhance sexual wellness or sexual fitness. In case of low levels of androgenic hormones in both sexes, the combination may contain as a further ingredient a sex hormone or a sex hormone precursor or a sex hormone stimulant or a sex hormone bioavailability enhancer.

专利号:US-11692058-B2
优先权日:2021-02-26
标题:Synthesis of functional polyurethanes and polyesters from biomass-derived monomers
发明人：CHANG HOCHAN; HUBER GEORGE W; DUMESIC JAMES A
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method of making polyesters and polyurethanes from biomass-derived polyols. The polyol is biomass-derived and has the structure:wherein dashed bonds are single or double bonds and R is selected from the group consisting of —OH and â•?O. Polyurethanes are made by reacting the polyol with a diisocyanate. Polyesters are made by reacting the polyol with a dicarboxylic acid.

专利号:EP-1587522-B1
优先权日:2003-01-13
标 题:Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins
发明人：ROHDEWALD PETER; FERRARI VICTOR
权利人:HORPHAG RES LUXEMBOURG HOLDING
摘要:PROBLEM TO BE SOLVED: To provide a method for enhancing sexual wellness or sexual fitness by administrating a source of proanthocyanidins and a source of arginine on a daily basis.SOLUTION: The method includes: proanthocyanidins stimulating an endothelial NO-synthase enzyme, which serves as a catalyst for synthesis of the nitric oxide from a substrate that is the source of the arginine; and a sufficient amount of the nitric oxide released over time to enhance sexual wellness or sexual fitness. In case of low levels of androgenic hormones in both sexes, the method further contains a sex hormone or a sex hormone precursor or a sex hormone stimulant or a sex hormone bioavailability enhancer, as a further ingredient.

专利号:US-6133280-A
优先权日:1997-02-05
标题 :Androgen synthesis inhibitors
发明人：BRODIE ANGELA; LING YANGZHI
权利人:UNIV MARYLAND
摘要:This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of synthesizing these novel compounds, pharmaceutical compositions containing these novel compounds, and methods of treating prostate cancer and benign prostatic hypertrophy using the androgen synthesis inhibitors of the present invention.

专利号:US-2014274978-A1
优先权日:2013-03-15
标题 :Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals
发明人：FASCIOLA ANDRE ARMEL
权利人:FASCIOLA ANDRE ARMEL
摘要:The present invention utilizes phytosterol, phytoecdysteroid, sapogenin, triterpene, terpene, spirostane, spirostene and androstene derivative compounds to provide a wide variety of utilities to humans and other animals. The compounds and methods provide numerous and wide-ranging benefits including biochemical and constructive metabolic benefits including increases in protein synthesis and synthesis efficiency, ergogenic, adaptogenic, cosmetic and medicinal skin agents and veterinary utilities. The compounds provide agents that increase physical endurance and work output, act as a general tonic for increasing health and vigor, increase sleep time and sleep efficiency and act as rejuvenating agents to reverse the effects of fatigue and stress. Novel utilities for pet, farm, zoo and companion animals are also provided.