CAS: 462651-80-5; Imidazo[1,2-A]Pyrimidin-7-Amine

相似化合物

274-95-3 6840-21-7 57473-41-3

上下游产品

CAS号107-20-0 一氯乙醛 | CAS号156-81-0 2,4-二氨基嘧啶

📜氯乙醛,2,4-二氨基嘧啶置于乙酸乙酯,Silica,Petroleum Ether Ethyl Acetate体系中,用 乙醇,碳酸氢钠 作为反应溶剂,化学反应 16.0H,以to Afford 199A As A White Solid (2.2 G,60%)的收率获得产物7-氨基咪唑并[1,2-A]嘧啶
参考文献:Heteroaryl Pyridone And Aza-Pyridone Compounds
标题:Heteroaryl Pyridone And Aza-Pyridone Compounds
摘要:提供了公式i的杂环吡啶酮和氮杂吡啶酮化合物,其中x1,X2和x3中的一个或两个为n,包括立体异构体,互变异构体和药学上可接受的盐,用于抑制btk激酶并治疗由btk激酶介导的免疫紊乱,如炎症.公开了使用公式i化合物进行哺乳动物细胞中的体外,原位和体内诊断和治疗这种疾病或相关病理条件的方法.

专利信息

专利号:US-11325912-B2
优先权日:2019-05-09
标题 :Regio-selective synthesis of imidazo[1,2-a]pyrimidines
发明人：CLAGG KYLE BRADLEY PASCUAL; WHITE NICHOLAS ANDREW; ZHANG HAIMING; GOSSELIN FRANCIS; NACK WILLIAM; O'SHEA PAUL D
权利人:GENENTECH INC
摘要:A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb)comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2This annulation reaction between β-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines. The reaction can be generalized to form imidazo[1,2-a]pyrimidines substituted at either of their 2- and 4-positions by alkoxy or thioalkyl groups.

专利号:US-2020369670-A1
优先权日:2019-05-09
标 题:REGIO-SELECTIVE SYNTHESIS OF IMIDAZO[1,2-a]PYRIMIDINES

专利号:WO-2020227576-A1
优先权日:2019-05-09
标题:Regio-selective synthesis of imidazo[1,2-a]pyrimidines