CAS: 438-41-5; Chlordiazepoxide Hydrochloride

上下游产品

chlordiazepoxide4-Benzoyl-6-chlor-3,4-dihydro-2-methylamino-chinoxalin amino>-N-methylacetamide2-(3-chlorophenyl)phenylmethyleneamino-N-methylacetamide 7-chloro-3,4-dihydro-2-methylamino-4-phenyl-5H-1,4-benzodiazepine-5-one demoxepam

📜氯氮卓置于盐酸体系中,用 丙酮 作为反应溶剂,化学反应 4.5H,以85.6%的收率获得产物盐酸氯氮卓
参考文献:一种制备引湿性小的盐酸氯氮卓的方法
标题:一种制备引湿性小的盐酸氯氮卓的方法
摘要:本发明公开一种制备引湿性小的盐酸氯氮卓的方法,包括如下步骤:(1)依次加入氯氮卓和小分子直链脂肪酮,搅拌升温至反应温度.缓慢滴加氯化氢丙酮溶液.滴加完毕后,保温反应,趁热过滤.洗涤,滤干,干燥得到盐酸氯氮卓粗品;(2)将盐酸氯氮卓粗品加入小分子直链脂肪酮中,搅拌升温至反应温度.保温反应,趁热过滤.洗涤,滤干,干燥得到盐酸氯氮卓.与现有的制备方法比较,本方法具有反应条件温和,生产工艺简单,过程容易控制,反应收率高,使用单一溶剂,母液便于回收,成本大大降低,适于工业化生产的优点.本方法制备的盐酸氯氮卓具有引湿性小,纯度高,稳定性好的优点.

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:WO-9412651-A1
优先权日:1992-12-01
标题 :Enzymatic synthesis of sugar alcohol esters
发明人：BARFOED MARTIN; SKAGERLIND JAN PETER
权利人:NOVO NORDISK AS; BARFOED MARTIN; SKAGERLIND JAN PETER
摘要:A method of preparing a compound of the general formula (I): R1-COO-X-O-R2, wherein R1-CO is the acyl group of a carboxylic acid which may be saturated or unsaturated, O-X-O is a saccharide moiety or a sugar alcohol moiety corresponding to a saccharide or a sugar alcohol of the general formula X(OH)¿2?, and R?2¿ is hydrogen, acetyl, or an alkyl group.

专利号:US-4309313-A
优先权日:1980-05-23
标题:Synthesis of cesium-containing zeolite, CSZ-1
发明人：BARRETT MICHAEL G; VAUGHAN DAVID E W
权利人:GRACE W R & CO
摘要:A new zeolite structure, CSZ-1, has a composition 0.05 to 0.55 M 2 O:0.45 to 0.95 Na 2 O:Al 2 O 3 : 3 to 7 SiO 2 :x H 2 O where M is cesium and/or thallium and x is 0 to 10. The zeolite has utility in sorption, separation and catalytic applications. It is made by reacting together sources of silica, alumina, soda, cesia and/or thallia, together with a nucleating agent or solution, followed by hot aging at a temperature between 50° and 160° C.

专利号:EP-2659897-A1
优先权日:2012-05-02
标 题 :Stem cell derived composition for the treatment of acute injury and degenerative diseases
发明人：CULMSEE CARSTEN; BLOMGREN KLAS; PFEIFER STEFANIE; OEXLER EVA-MARIA; SATO YOSHIAKI; ZHU CHANGLIAN
权利人:UNIV MARBURG PHILIPPS
摘要:The invention comprises a composition obtained from dying pluripotent neural stem and progenitor cells undergoing cell death that is useful for the treatment of acute injury and degenerative diseases. Furthermore, a method for synthesis of the composition according to the invention is provided.

专利号:US-2023399688-A1
优先权日:2015-08-20
标 题 :Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them
发明人：CULLER STEPHANIE; CHEN IHSIUNG BRANDON; PHARKYA PRITI; VAN DIEN STEVE; BARTON NELSON
权利人:GENOMATICA INC
摘要:In alternative embodiments, provided herein are transcription/translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).