CAS: 40643-55-8; 2-(Methyl(Phenyl)Amino)Acetic Acid

相似化合物

21911-75-1 93-90-3 23582-63-0

上下游产品

(N-methylanilino)acetonitrile 2-(o-tolylamino)acetamide chloroacetic acid ethyl ester N,N-dimethyl-anilineN,N-dimethyl-aniline N,N-dimethyl-anilineN,N-dimethyl-aniline methylammonium carbonate 4-chlorobenzyl N-methyl-N-phenylglycinate acetophenone

📜2-(甲基(苯基)氨基)乙腈置于sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 5.0H,以87%的收率获得产物n-苯基-N-甲基甘氨酸
参考文献:好氧钌催化叔胺与氰化钠氧化氰化
标题:好氧钌催化叔胺与氰化钠氧化氰化
摘要:Rucl3 催化叔胺与氰化钠在分子氧 (1 Atm) 下在 60oc 氧化氰化得到相应的 α-氨基腈,它们是各种化合物的多功能合成中间体,如氨基酸和不对称 1,2-二胺,在非常好的产量.这种反应是干净的,应该是一个对环境无害且有用的过程.
DOI:10.1021/ja0390303

专利信息

专利号:WO-2011106929-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO
权利人:MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO
摘要:Compounds of formula I that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infection and for inhibiting HCV viral replication and /or viral production in a cell-based system.

专利号:US-10865163-B2
优先权日:2017-12-20
标题:Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
发明人：YOUNG MICHAEL C; KAPOOR MOHIT
权利人:UNIV TOLEDO
摘要:Methods of synthesizing compounds using CO 2 as a directing group for C—H functionalization, and compounds made thereby, are described.

专利号:US-2012328569-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-2019185392-A1
优先权日:2017-12-20
标 题 :Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds

专利号:US-6759551-B1
优先权日:2000-11-03
标题:Chiral (s- or r-methylphenylglycine) amino acid crystal and method for preparing same
发明人：PELTA ISABELLE; MARET JEAN-CLAUDE
权利人:BAYER CROPSCIENCE SA
摘要:The invention concerns chiral amino acid, is preparation method, and the use of said chiral amino acid as intermediate for the synthesis of chiral organic compounds.

专利号:US-9783800-B2
优先权日:2014-02-03
标 题:Method for producing peptides having azole-derived skeleton
发明人：SUGA HIROAKI; GOTO YUKI; KATO YASUHARU
权利人:UNIV TOKYO
摘要:Object of the present invention is to develop an artificial synthesis system of various peptides having an azole derivative structure and develop a library of such peptides. The present invention provides a method of producing a peptide having, in the backbone thereof, an azole derivative structure comprising the step of: synthesizing a substrate peptide of an azoline structure introducing enzyme having, in the modified region thereof, at least any one of the following amino acids, n n[in any of the compounds,n X 1 represents a group selected from the group consisting of SH, OH, NH 2 , SR 1 , OR 1 , NHR 1 , and N 3 (R 1 represents a protecting group), X 2 represents an easily eliminable group; and X 3 represents hydrogen or a substituted or unsubstituted alkyl or aryl group having from 1 to 10 carbon atoms]; reacting the substrate peptide with an azoline structure introducing enzyme to obtain a peptide having an azoline derivative structure; and converting the azoline derivative structure of the resulting peptide into an azole derivative structure by inducing an HX 2 elimination reaction of X 2 group.