CAS: 405060-95-9; (E)-N-(2,2,2-Trichloro-1-(3-(Quinolin-8-yl)Thioureido)Ethyl)Cinnamamide
该化合物是一种合成有机化合物,其结构复杂,包括一种丙胺脊柱,一种苯基和一种quinonsoy.该化合物具有多种功能组,包括矿泉和三氧甲基组,有助于其潜在的生物活动.三氯组的存在表明,该物质在生物系统中可能具有独特的再活动性和互动性.quinoline结构往往与各种药理特性有关,包括抗微生物和抗癌活动.该化合物的配置(2E)表明,该化合物的具体立体化学学在其生物互动和功效方面发挥着关键作用.
- 英文名称(E)-N-(2,2,2-Trichloro-1-(3-(Quinolin-8-yl)Thioureido)Ethyl)Cinnamamide
- 中文名称(E)-N-(2,2,2-三氯-1-(3-(喹啉-8-基)硫脲基)乙基)肉桂酰胺
- IUPAC名称N-(2,2,2-trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide
- 其它别名(2E)-3-Phenyl-N-{2,2,2-Trichloro-1-[(Quinolin-8-Ylcarbamothioyl)Amino]Ethyl}Prop-2-Enamide; 2-Propenamide, 3-Phenyl-N-[2,2,2-Trichloro-1-[[(8-Quinolinylamino)Thioxomethyl]Amino]Ethyl]
- CAS编号405060-95-9
- MFCD编号:MFCD00548612
- EINECS号:809-398-8
- FDA UNII编号:J8PSF5Z8KJ
- 分子式:C21H17Cl3N4OS分子量:479.82
- 产品CID: 1418450
- 产品分类生物化工 → 抑制剂 → 细胞凋亡 → PERK 激活剂
物理性质
- 熔点>160°C (分解)
- 沸点160 °C (分解)>>160 °C (分解)
- 密度1.5±0.1 g/cm3
- pKa:10.70±0.70(预测)
- PSA:98.14
- LogP:6.21
- 折射率1.732
- 溶解性DMSO: Soluble20mg/mL, Clear
- 敏感性光敏感
- 外观形态白色至淡黄色至浅灰色粉末
- 储存条件-20°C
- 产品应用该化合物用作抑制内分光性内膜内膜外露(ER)应激调节骨质中毒(EC50 15 微米);抑制TONICAYCIN(TM)引起的DNA分裂和气酶-7激活;加强非快速眼运动(NREM)睡眠;抑制外疹复发(HSV)(IC50 = 3 ΜM)在体外和在老鼠角膜感染模型中复制(IC 50 =3 微克M),并调节对内分泌管的恒定状态睡眠反应.
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2902500000-苯乙烯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Mu Z, Li B, Chen M, Liang C, Gu W, Su J. Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway. Mol Med Rep. 2024 Dec;30(6):235. doi: 10.3892/mmr.2024.13360. Epub 2024 Oct 18. 14(19):1564. doi: 10.3390/nano14191564.
3: Isaac AR, Chauvet MG, Lima-Filho R, Wagner BA, Caroli BG, Leite REP, Suemoto CK, Nunes PV, De Felice FG, Ferreira ST, Lourenco MV. Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans. Transl Psychiatry. 2024 Oct 1;14(1):397. doi: 10.1038/s41398-024-03128-y.
4: Hossain MG, Ueda K. Regulation of Hepatitis B Virus Replication by Modulating Endoplasmic Reticulum Stress (ER-Stress). Int J Microbiol. 2024 Aug 30;2024:9117453. doi: 10.1155/2024/9117453.
合成参考文献
参考文献:10.1097/cej.0b013e32834473c3
摘要:Shin JA, Shim JH, Choi ES, Leem DH, Kwon KH, Lee SO, Safe S, Cho NP, Cho SD. Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells. Eur J Cancer Prev. 2011 Sep;20(5):417–25. doi: 10.1097/cej.0b013e32834473c3.
参考文献:10.1016/j.freeradbiomed.2011.04.038
摘要:Wu CT, Sheu ML, Tsai KS, Chiang CK, Liu SH. Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model. Free Radic Biol Med. 2011 Aug 01;51(3):671–80. doi: 10.1016/j.freeradbiomed.2011.04.038.
参考文献:10.1007/s12035-015-9463-0
摘要:Goswami P, Gupta S, Biswas J, Sharma S, Singh S. Endoplasmic Reticulum Stress Instigates the Rotenone Induced Oxidative Apoptotic Neuronal Death: a Study in Rat Brain. Mol Neurobiol. 2016 Oct;53(8):5384–400. doi: 10.1007/s12035-015-9463-0.
参考文献:10.14348/molcells.2017.2259
摘要:Rani S, Sreenivasaiah PK, Cho C, Kim DH. Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway. Molecules and Cells. 2017 Jan;40(1):66–72. doi: 10.14348/molcells.2017.2259.
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