CAS: 344770-47-4; Dimorpholinopyridazinone

专利信息

专利号:WO-2005089783-A1
优先权日:2004-03-22
标题:Lipoprotein lipase activity inhibitor
发明人：SEKI TOSHIHIKO; YAGI EIICHIRO
权利人:SHISEIDO CO LTD; SEKI TOSHIHIKO; YAGI EIICHIRO
摘要:A lipoprotein lipase activity inhibitor which inhibits fat accumulation in fat cells. Namely, an enzyme lipoprotein lipase (LPL), which is regenerated by fat cells and secreted into peripheral vessels in epithelial cells by exocytose, decomposes fat having been absorbed into the vessels as foods into fatty acids and glycerol. Then the fatty acids and glycerol migrate into fat cells in the subcutaneous fat tissue and fat is finally synthesized in the fat cells. By applying the above-described lipoprotein lipase activity inhibitor to the skin as an external skin preparation for slimming, therefore, the action of the enzyme lipoprotein lipase (LPL) can be inhibited in peripheral vessels in epithelial cells. As a result, the decomposition of fat into fatty acid and glycerol can be inhibited and the synthesis of new fat in fat cells can be finally prevented. Thus, slimming effect can be established.