CAS: 23039-94-3; Tris(3-Fluorophenyl)Phosphine

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3-fluorobromobenzene6H4F-m)3(CO)3NiP(C6H4F-m)3 cis-dichlorobis{tris(3-fluorophenyl)phosphane}platinum(II) [(acetyl)(tris(m-fluorophenyl)phosphine)Co(CO)3]

📜间溴氟苯置于magnesium,三氯化磷体系中,用 乙醚 用作溶剂,化学反应 3.0H,以42%的收率获得三(3-氟苯基)膦
参考文献:磷取代基对α-烷氧基phosph盐与亲核试剂反应的影响
标题:磷取代基对α-烷氧基phosph盐与亲核试剂反应的影响
摘要:研究了磷取代基对α-烷氧基salts盐与亲核试剂反应性的影响.由各种缩醛和三(邻甲苯基)膦制备的α-烷氧基phosph盐与各种亲核试剂的反应有效进行.这些过程代表了α-烷氧基phosph盐高亲核取代反应的第一个例子.这些盐的反应性分别取决于空间和电子因素之间的平衡,分别由锥角θ和co拉伸频率ν(分别为空间和电子参数)表示.此外,由ph 3衍生的α-烷氧基phosph盐的新反应观测到带有格氏试剂的p在o 2的存在下发生,以高收率得到醇.为此过程提出了一种自由基机理,该机理已获得同位素标记和自由基抑制实验的支持.
Doi:10.1002/chem.201200480

专利信息

专利号:US-7902376-B2
优先权日:2008-01-23
标 题 :Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates
发明人：XU FENG; KIM MARY M; KOHMURA YOSHINORI; SLADICKA TRICIA; ROSEN JONATHAN D; ZACUTO MICHAEL J
权利人:MERCK SHARP & DOHME; BANYU PHARMA CO LTD
摘要:A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I): n nwherein Ar is optionally substituted phenyl and P is a primary amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

专利号:CN-117402099-A
优先权日:2023-10-16
标题 :A kind of synthesis method of multi-substituted pyrrole compounds