CAS: 22223-49-0; Methyl 2-Amino-3-Methylbenzoate

上下游产品

methanol 3-methylantranilic acid methyl 3-methyl-2-nitrobenzoate diazomethanemethyl 2-cyano-3-methylbenzoate 5-phosphanylidene)-ethanone1-(2-Amino-3-methyl-phenyl)-2-(triphenyl-λ5-phosphanylidene)-ethanone Methyl 3-methyl-2-methylaminobenzoate 2-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)-3-methyl-benzoic acid methyl ester

3-甲基-2-硝基苯甲酸甲酯置于铁粉,氯化铵体系中,用 乙醇,水 用作溶剂,化学反应 4.0H,以85%的收率获得2-氨基-3-甲基苯甲酸甲酯
参考文献:One-Pot Synthesis Of Novel 3,5-Disubstituted-1,2,4-Oxadiazoles From Indazole Carboxylic Acid Esters And Amidoximes
标题:One-Pot Synthesis Of Novel 3,5-Disubstituted-1,2,4-Oxadiazoles From Indazole Carboxylic Acid Esters And Amidoximes
摘要:本文描述了一种高效且高产率的一锅法合成3,5-二取代-1,2,4-噁二唑的方法,该方法从吲唑羧酸甲酯和酰肟出发.在本研究中,利用酰肟2A-D和吲唑羧酸酯(3-6)合成了一系列新型3,5-二取代-1,2,4-噁二唑(3A-D),(4A-D),(5A-D),(6A-D),(7A-D).
Doi:10.14233/ajchem.2014.15564

专利信息

专利号:EP-1025077-B1
优先权日:1997-10-15
标题 :Novel aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN RICHARD; REN JIANXIN
权利人:WYETH CORP
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having formula (I) wherein: R?1 and R2¿ are, independently, selected from H; C¿1?-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R?3, R4, R5, and R6¿ are independently selected from H, halogen, -NO¿2?, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R?1¿, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO¿2?-R?1, -SO¿2-Ar, -CO-R1, -CO-Ar, -CO¿2-R?1, or -CO¿2?-Ar; and Y is selected from a) the moiety (i) wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:US-6268504-B1
优先权日:1997-10-15
标题 :Aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN R; REN JIANXIN; IERA SILVIO
权利人:AMERICAN HOME PROD
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, -NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R1, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO2-R1, -SO2-Ar, -CO-R1, -CO-Ar, -CO2-R1, or -CO2-Ar; and Y is selected from a) the moiety:wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:US-5437991-A
优先权日:1994-05-02
标 题:Process for the synthesis natural aromatics
发明人：KITTLESON JEANINE R; PANTALEONE DAVID P
权利人:NUTRASWEET CO
摘要:A novel method for the production of natural aromatic ester compounds such as methyl anthranilate, ethyl anthranilate butyl anthranilate methyl cinnamate and methyl salicylate comprises the esterification of their corresponding acids using microbially derived enzymes in the presence of a C1-C4 alcohol such as methanol, ethanol or butanol. A biphasic reaction medium may optionally be utilized to generate maximum yields through the addition of a non-polar organic solvent such as hexane, ethyl acetate, heptane and the like.

专利号:US-12404250-B2
优先权日:2018-08-27
标 题:PARP inhibitors for treating cancer and asthma
发明人：COHEN MICHAEL; KIRBY ILSA
权利人:UNIV OREGON HEALTH & SCIENCE
摘要:Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.