CAS: 21215-62-3; Calcitonin, Human

该化合物是一种32-氨酸激素,它涉及碳化钙,主要抑制骨质疏导骨吸附,促进肾化钙排泄,这种合成形式复制了内生人类碳化物,确保高度的生物兼容性和活动,广泛用于研究和临床应用,特别是用于研究钙代谢,骨质疏松症和高血糖,产品具有高纯度(>95%)和严格的质量控制特征,确保了实验和治疗研究的可靠性能,其稳定性和明确界定的结构使其适合体外和体外调查.Calcitonin(人类)是内分泌研究和药理学发展的关键工具.

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    专利号:EP-1566438-A2
    优先权日:1998-10-13
    标 题:Stabilized bioactive peptides and methods of identification, synthesis and use
    发明人:ALTMAN ELLIOT
    权利人:UNIV GEORGIA RES FOUND
    摘要:An intracellular selection system allows concurrent screening for peptide bioactivity andnstability. Randomized recombinant peptides are screened for bioactivity in a tightly regulatednexpression system, preferably derived from the wild-type lac operon. Bioactive peptides thusnidentified are inherently protease- and peptidase-resistant. Also provided are bioactive peptidesnstabilized by a stabilizing group at either the N-terminus, the C-terminus, or both. Thenstabilizing group can take the form of a small stable protein, such as the Rop protein,nglutathione sulfotransferase, thioredoxin, maltose, binding protein, or glutathione reductase, ornone or more proline residues.

    专利号:US-2018313820-A1
    优先权日:1998-10-13
    标 题 :Stabilized bioactive peptides and methods of identification, synthesis, and use

    专利号:US-2003190740-A1
    优先权日:1998-10-13
    标题 :Stabilized bioactive peptides and methods of identification, synthesis, and use

    专利号:CA-2493306-A1
    优先权日:2002-07-31
    标题:Stabilized bioactive peptides and methods of identification, synthesis, and use

    专利号:US-2012059145-A1
    优先权日:1998-10-13
    标 题 :Stabilized bioactive peptides and methods of identification, synthesis, and use

    专利号:WO-2010039913-A1
    优先权日:2008-10-01
    标 题 :Calcilytic compounds
    发明人:DEMARTINO MICHAEL P; JEONG JAE U; MARQUIS ROBERT W JR; RAMANJULU JOSHI M
    权利人:GLAXOSMITHKLINE LLC; DEMARTINO MICHAEL P; JEONG JAE U; MARQUIS ROBERT W JR; RAMANJULU JOSHI M
    摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

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