CAS: 19395-40-5; Phenyl(2-Piperidinyl)Acetic Acid Hydrochloride (1:1)

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threo-methyl α-phenyl-α-(2-piperidyl)acetate hydr°Chloride

📜盐酸哌甲酯置于盐酸体系中,化学反应 24.0H,反应生成2-苯基-2-(哌啶-2-基)乙酸盐酸盐
参考文献:Synthesis And Pharmacology Of Ethylphenidate Enantiomers: The Human Transesterification Metabolite Of Methylphenidate And Ethanol
标题:Synthesis And Pharmacology Of Ethylphenidate Enantiomers: The Human Transesterification Metabolite Of Methylphenidate And Ethanol
摘要:Ethanol Elevates Methylphenidate (1) Plasma Concentrations And Yields The Metabolite Ethylphenidate (2). The Therapeutic Implications Are Under Investigation. The Ic50 For Dopamine Reuptake Inhibition By (+)-2 Was 27 Nm Compared To 367 Nm For Cocaine And 1730 Nm For (-)-2. Binding Selectivity For Dopamine Versus Norepinephrine Transporters Was Greater For (+)-2 Than For Cocaine. Intraperitoneal (+)-2 Was Approximately Half As Active As (+)-1 In Stimulating Mouse Motor Activity At 5 Mg/kg,But (+)-2 Was As Active As (+)-1 At 10 Mg/kg.
Doi:10.1021/jm0490989