CAS: 175883-63-3; 3-Chloro-4-Methylphenylboronic Acid

上下游产品

CAS号13195-76-1 硼酸三异丁酯

三异丁基硼酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醚体系中,化学反应生成3-氯-4-甲基苯硼酸
参考文献:Mel'Nikow; Rokizkaja,Zhurnal Obshchei Khimii,1938,Vol. 8,P. 1768,1772
标题:Mel'Nikow; Rokizkaja,Zhurnal Obshchei Khimii,1938,Vol. 8,P. 1768,1772

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.