CAS: 1635-31-0; 3-Amino-2H-Chromen-2-One

上下游产品

3-acetamid°Coumarin 1-thiopropane 3-azido-2H-chromen-2-one 3-benzamid°Coumarin H-chromeno[3,4-b]pyrrol-4-one1-methyl-2-phenyl-3H-chromeno[3,4-b]pyrrol-4-one H-chromeno[3,4-b]pyrrol-4-one2-methyl-1-phenyl-3H-chromeno[3,4-b]pyrrol-4-one N-(2-oxo-2H-1-benzopyran-3-yl)phthalamic acid 3-(N-tosyl-L-Ala)amin°Coumarin

📜香豆素-3-羧酸置于叠氮磷酸二苯酯,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 17.0H,反应生成3-氨基香豆素
参考文献:探索 3,4-未取代香豆素作为硫氧还蛋白还原酶 1 抑制剂用于癌症治疗
标题:探索 3,4-未取代香豆素作为硫氧还蛋白还原酶 1 抑制剂用于癌症治疗
摘要:香豆素及其衍生物已成为药物发现领域有希望的候选者.虽然香豆素作为具有不同生物靶点的抗癌药物的活性已被彻底研究,但有关香豆素抑制硫氧还蛋白还原酶(trxr)的潜力的报道仍然很少.我们专注于 3,4-未取代香豆素类似物的设计和合成,并在香豆素的第五至第八位上系统地引入取代基,从而可以进行明确的结构-活性关系分析.在获得的文库中,香豆素核心的第六位被芳族基团或环丙基取代被证明更加增强了活性.根据对接结果,具有大cf 3基团的大芳香族取代基以能够与催化trxr1残基形成共价键的方式促进配体排列.我们的观察表明,一系列香豆素类似物对硫氧还蛋白还原酶 1 (Trxr1) 的活性取决于取代基的性质(大小和电子效应)和位置,更重要的是-迈克尔受体功能的可及性.在体外基于细胞的测定中进一步检查了几种化合物(在 200 μm 浓度下对大鼠 Trxr1 酶具有至少 90% 的抑制作用),以评估对各种癌细胞系的细胞毒性作用.选择类似物
Doi:10.1039/d3Ob01522J

专利信息

专利号:US-2003182068-A1
优先权日:2001-10-30
标 题 :Device and methods for directed synthesis of chemical libraries
发明人：BATTERSBY BRONWYN J; MILLER CHRISTOPHER R; TRAU MATHIAS; WAY JEFFERY C; JOHNSTON ANGUS
摘要:The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.

专利号:WO-9410327-A1
优先权日:1992-10-28
标 题 :Enzymatic synthesis of polyaniline
发明人：ZEMEL HAYA; QUINN JOHN F
权利人:ALLIED SIGNAL INC
摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

专利号:US-5420237-A
优先权日:1991-08-29
标 题:Enzymatic synthesis of polyaniline
发明人：ZEMEL HAYA; QUINN JOHN F
权利人:ALLIED SIGNAL INC
摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:US-9115358-B2
优先权日:2006-08-11
标题 :Moenomycin biosynthesis-related compositions and methods of use thereof
发明人：WALKER SUZANNE; OMELYANOVICH OSTASH BOHDAN
权利人:WALKER SUZANNE; OMELYANOVICH OSTASH BOHDAN; HARVARD COLLEGE
摘要:The methods and compositions described herein relate to the identification, isolation, and characterization of genes which encode proteins useful for the biosynthesis of transglycosylase inhibitors such as moes. The methods and compositions also relate to the production of such proteins, and their use in the synthesis of moes, the expression of moes, and the production of modified moes.