CAS: 156474-22-5; Tert-Butyl ((R)-1-((S)-Oxiran-2-yl)-2-Phenylethyl)Carbamate
该化合物是有机化合物,具有独特的结构特征,含有氧化物功能组,由三名成员组成,有助于其在有机合成中进行反应和潜在应用;N-Boc(乙氧碳基)保护组在氨基功能上的存在表明,该化合物可能用于浸泡合成或作为制造更复杂的分子的中间体.由(2S,3R)标明的立体化学学表明,原子的具体空间安排可以影响该化合物的生物活动和相互作用.此外,丁烷链中的苯基组会增强化合物的湿气特性,有可能影响其溶解性和再活性.
- 英文名称Tert-Butyl ((R)-1-((S)-Oxiran-2-yl)-2-Phenylethyl)Carbamate
- 中文名称((R)-1-((S)-环氧乙烷-2-基)-2-苯乙基)氨基甲酸叔丁酯
- 其它别名(2S,3R)-3-(叔丁氧羰基氨基)-1,2-环氧-4-苯基丁烷; (2S,3R)-3-(N-Boc-Amino)-1-Oxirane-4-Phenylbutane
- CAS编号156474-22-5
- MFCD编号:MFCD08061626
- FDA UNII编号:73T4J3BKK8
- 分子式:C15H21NO3分子量:263.33
- 产品CID: 779114
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
98737-29-2 98760-08-8 98737-29-2物理性质
MSDS等安全信息
上下游产品
(R)-N-(tert-butoxycarbonyl)-3-amino-4-phenyl-1-butene ((1R,2R)-1-Benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid tert-butyl ester ((1R,2R)-1-Benzyl-2-hydroxy-3-isopropylamino-propyl)-carbamic acid tert-butyl ester ((1R,2R)-1-Benzyl-2-hydroxy-3-methylamino-propyl)-carbamic acid tert-butyl ester ((1R,2R)-1-Benzyl-3-benzylamino-2-hydroxy-propyl)-carbamic acid tert-butyl ester合成工艺路线路线简述
- 合成目标产物 (2S,3R)-3-(N-Boc-Amino)-1-Oxirane-4-Phenylbutane 主要起始原料 3R Enantiomer
- (文献来源)合成步骤主要原料 3R Enantiomer
📜2-甲基-2-丙基[(2R)-1-苯基-3-丁烯-2-基]氨基甲酸酯置于间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,化学反应生成(2S,3R)-3-(叔丁氧羰基氨基)-1,2-环氧-4-苯基丁烷
参考文献:Stereochemical Analysis Of (Hydroxyethyl)Urea Peptidomimetic Inhibitors Of γ-Secretase
标题:Stereochemical Analysis Of (Hydroxyethyl)Urea Peptidomimetic Inhibitors Of γ-Secretase
摘要:(Hydroxyethyl)Urea Peptidomimetics Systematically Altered At Positions P2-P3' With Hydrophobic D-Amino Acids Were Synthesized. An All D-Amino Acid Containing Analogue Was Identified That Effectively Blocked Gamma-Secretase Activity In A Cell-Free System (Ic50 = 30 Nm). Systematic Alteration Of The Stereocenters Of A Potent Compound Revealed Interdependence Between The Various Positions. Although Typically Less Potent Than Their L-Peptidomimetic Counterparts. Selected All D-Amino Acid Containing Analogues Were Equipotent. To Their Counterparts In A Cell-Based Assay When Incubated For Extended Times.
Doi:10.1021/jm049566E
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2910100000-环氧乙烷 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6649639-B2
优先权日:1997-03-28
标 题 :Antipicornaviral compounds, compositions containing them, and methods for their use
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU
摘要:Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
专利号:US-6020371-A
优先权日:1997-03-28
标题 :Antipicornaviral compounds compositions containing them and methods for their use
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU
权利人:AGOURON PHARMA
摘要:Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
专利号:EP-0975588-B1
优先权日:1997-03-28
标 题:Antipicornaviral compouds, compositions containing them, and methods for their use
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU
权利人:AGOURON PHARMA
摘要:Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds of formula (I), wherein M is O or S, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Catalytic Formation Of Cyclic Carbonates Using Gallium Aminotrisphenolate Compounds And Comparison To Their Aluminium Congeners: A Combined Experimental And Computational Study作者:Lucía álvarez‐miguel,Jesús Damián Burgoa,Marta E. G. Mosquera,Alex Hamilton,Christopher J. Whiteoak |发布日期:2021.10.7
摘要:Of Gallium Aminotrisphenolate Compounds As Catalysts For The Synthesis Of Cyclic Carbonates From Epoxides And Co2. The Results Show That They Are Highly Active, And More So Than The Corresponding Aluminium Congeners. The Catalyst System Is Applicable At Low And Elevated Temperatures Across A Wide Substrate Scope Including Terminal, Internal, Multiple And Fully Deuterated Epoxides. Applying Low Catalyst
合成参考文献
参考DOI号:10.1021/ja000461k
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