CAS: 153034-88-9; 2-Chloro-4-Iodo-3-Methylpyridine

相似化合物

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CAS号78607-36-0 2-氯-3-碘吡啶 | CAS号74-88-4 碘甲烷 | CAS号787596-41-2 2-氯-3-甲基异烟酸甲酯 | CAS号1035946-00-9 1-(2-氯-3-甲基-吡啶-...

2-氯-3-碘吡啶,碘甲烷置于lithium Diisopropyl Amide体系中,用 四氢呋喃 用作溶剂,以69%的收率获得2-氯-4-碘-3-甲基吡啶
参考文献:First Metalation Of Aryl Iodides: Directed Ortho-Lithiation Of Iodopyridines,Halogen-Dance,And Application To Synthesis
标题:First Metalation Of Aryl Iodides: Directed Ortho-Lithiation Of Iodopyridines,Halogen-Dance,And Application To Synthesis
摘要:Metalation Of Iodopyridines Was Successfully Achieved By Lda At Low Temperature. In Many Cases,Lithiation Is Ortho Directed By The Iodo Group Which Subsequently Ortho-Migrates Very Fast To Give Stabilized Iodolithiopyridines. This Procedure Was Applied To 2-Fluoro-And 2-Chloro-3-Iodopyridines,3-Fluoro-4-Iodopyridine,And 2-Chloro-3-Fluoro-4-Iodopyridine. The Resulting Lithio Intermediates Were Obtained In High Yields Before Being Reacted With Electrophiles Leading To Various Polysubstituted Pyridines. Some Of These Iodopyridines Were Used As Key Molecules For The Synthesis Of Fused Polyaromatic Alkaloids. Thus,Perlolidine,Delta-Carbolines,And 2,10-Diazaphenanthrenes Were Readily Prepared In Few Steps Taking Advantage Of The Iodo Reactivity For Heteroring Cross-Coupling.
Doi:10.1021/jo00079A031

专利信息

专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:WO-2004080960-A2
优先权日:2003-03-06
标题 :Methods and compositions for the enzymatic synthesis of gangliosides

专利号:WO-2011011384-A2
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:EP-1603932-A2
优先权日:2003-03-06
标 题 :Methods and compositions for the enzymatic synthesis of gangliosides