CAS: 146328-87-2; 5-Cyano-2-Fluorobenzoic Acid

相似化合物

550363-85-4 327-95-7 146137-79-3

上下游产品

CAS号337362-21-7 5-氰基-2-氟苯甲酸甲酯 | CAS号7758-19-2 亚氯酸钠 | CAS号10049-21-5 磷酸二氢钠单水合物 | CAS号146137-79-3 5-氰基-2-氟苯甲醛 | CAS号124-38-9 二氧化碳 | CAS号1194-02-1 对氟苯腈

📜5-溴-2-氟苯甲醛置于双氧水,Sodium Sulfite体系中,用 N-甲基乙酰胺,水,乙腈 用作溶剂,化学反应生成5-氰基-2-氟苯甲酸
参考文献:Anthranilic Acid Derivatives As Inhibitors Of The Cgmp-Phosphodiesterase
标题:Anthranilic Acid Derivatives As Inhibitors Of The Cgmp-Phosphodiesterase
摘要:式(I)的化合物 其中r1为氢;R2为硝基,氰基或卤素(较低)烷基;R3为苯基,其上取代一个或多个卤素,氰基和较低烷氧基的取代基;A为较低烷基烯基;R4为一个基团cr6R7R8,其中r6和r7与它们连接的碳原子一起形成一个环烷基,可选择地取代羟基,较低烷氧基或较低烷酰氨基;而r8为氢;其前药和盐.

专利信息

专利号:US-9700543-B2
优先权日:2011-05-31
标题 :GLP-1 receptor stabilizers and modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; BRAHMACHARY ENUGURTHI; YEAGER ADAM RICHARD
权利人:CELGENE INT II SÀRL
摘要:Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1(7-36), GLP-1(9-36), oxyntomodulin and exendin variants.