CAS: 1434141-81-7; Tert-Butyl 3,3-Difluoro-4-Hydroxypyrrolidine-1-Carboxylate

相似化合物

1873374-41-4 1638764-82-5 2165974-26-3

上下游产品

tert-butyl 3-(benzyloxy)-4-oxopyrrolidine-1-carboxylate tert-butyl 4-(benzyloxy)-3,3-difluoropyrrolidine-1-carboxylate tert-butyl dicarbonatedi-tert-butyl dicarbonate 1-benzyl-4,4-difluoropyrrolidin-3-ol tert-butyl 4-amino-3,3-difluoropyrrolidine-1-carboxylate

📜Tert-Butyl 3-(Benzyloxy)-4-Hydroxypyrrolidine-1-Carboxylate置于palladium Hydroxide 10 Wt. % On Activated Carbon,氢气,戴斯-马丁氧化剂,[双(2-甲氧基乙基)胺]三氟化硫体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 32.0H,反应生成1-Boc-3,3-二氟-4-羟基吡咯烷
参考文献: Purine Inhibitors Of Human Phosphatidylinositol 3-Kinase Delta[fr] Inhibiteurs Puriques De La Phosphatidylinositol 3-Kinase Delta Humaine
标题: Purine Inhibitors Of Human Phosphatidylinositol 3-Kinase Delta[fr] Inhibiteurs Puriques De La Phosphatidylinositol 3-Kinase Delta Humaine
摘要:本发明提供了一种公式i的化合物,这些化合物是pi3K-δ抑制剂,因此可用于治疗pi3K-δ介导的疾病,如炎症,哮喘,慢性阻塞性肺疾病和癌症.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.