CAS: 110101-66-1; (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-Dipyrrolidin-1-Ylpyrimidin-4-yl)Piperazin-1-Yl]Acetyl]-10,13,16-Trimethyl-6,7,8,12,14,15,16,17-Octahydrocyclopenta[a]Phenanthren-3-One

上下游产品

4-(1-哌嗪)-2,6-双-(1-吡咯烷)-嘧啶 4-(1-Piperazinyl)-2,6-Di-1-Pyrrolidinylpyrimidine 111641-17-9

📜2,4-Di(1-Pyrrolidinyl)-6-Chloropyrimidine置于吡啶,Potassium Carbonate,Sodium Iodide体系中,用 乙腈 用作溶剂,化学反应 92.0H,反应生成替拉扎特
参考文献:Novel 21-Aminosteroids That Inhibit Iron-Dependent Lipid Peroxidation And Protect Against Central Nervous System Trauma
标题:Novel 21-Aminosteroids That Inhibit Iron-Dependent Lipid Peroxidation And Protect Against Central Nervous System Trauma
摘要:A Novel Class Of 21-Aminosteroids Has Been Developed. Compounds Within This Series Are Potent Inhibitors Of Iron-Dependent Lipid Peroxidation In Rat Brain Homogenates With Ic50'S As Low As 3 Microm. Furthermore,Selected Members Enhance Early Neurological Recovery And Survival In A Mouse Head Injury Model. Significant Improvement In The 1 H Post-Head-Injury Neurological Status (Grip Test Score) By As Much As 168.6% Of The Control Has Been Observed. The Most Efficacious Compound In This Assay (30) Showed An Increase In The 1-Week Survival Of 78.6% As Compared To 27.3% For The Vehicle-Treated Mice In The Head-Injury Model. Based On Its Biological Profile,21-[4-(2,6-Di-1-Pyrrolidinyl-4-Pyrimidinyl)-1-Piperazinyl]-16 Alpha-Methylpregna-1,4,9(11)-Triene-3,20-Dione Monomethanesulfonate (30) Was Selected For Further Evaluation And Is Currently Entering Phase I Clinical Trials For The Treatment Of Head And Spinal Trauma.
Doi:10.1021/jm00166A010

专利信息

专利号:US-6355416-B1
优先权日:1997-02-14
标 题:Assay for the measurement of DNA synthesis rates
发明人：ABRAMSON FRED P
权利人:UNIV GEORGE WASHINGTON
摘要:Use of nonradioactive tracer technology used to measure DNA synthesis rates. DNA synthesis is determined by administering one or more stable isotope labelled precursors to one or more of DNA molecules and the amount of the stable isotope label in the DNA that is extracted from cells that are of interest is measured.

专利号:WO-2023016817-A1
优先权日:2021-08-12
标 题:Synthesis of delta 9,11 steroids

专利号:US-2024327451-A1
优先权日:2021-08-12
标 题:Synthesis of Delta 9,11 Steroids

专利号:US-2014228303-A1
优先权日:2011-06-13
标题 :Novel sglt inhibitors
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).

专利号:EP-4384529-A1
优先权日:2021-08-12
标题:Synthesis of delta 9,11 steroids

专利号:CN-117858886-A
优先权日:2021-08-12
标题 :Synthesis of Δ9,11-steroids