CAS: 1034924-06-5; (2-Methylpyrimidin-5-yl)Boronic Acid

相似化合物

1052686-67-5 1164100-81-5 109299-78-7

上下游产品

5-bromo-2-methylpyrimidine (3S)-N,N-dibenzyl-5-(2-methylpyrimidin-5-yl)chroman-3-amine N-[(4aR,8aS)-8a-(2,4-difluorophenyl)-6-(2-methylpyrimidin-5-yl)-4,4a,8,8a-tetrahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide

2-甲基-5-溴嘧啶置于正丁基锂,硼酸三异丙酯体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 1.0H,反应生成2-甲基嘧啶-5-硼酸
参考文献: Purine Inhibitors Of Human Phosphatidylinositol 3-Kinase Delta[fr] Inhibiteurs Puriques De La Phosphatidylinositol 3-Kinase Delta Humaine
标题: Purine Inhibitors Of Human Phosphatidylinositol 3-Kinase Delta[fr] Inhibiteurs Puriques De La Phosphatidylinositol 3-Kinase Delta Humaine
摘要:这项即时发明提供了式(I)的化合物,这些化合物是pi3K-δ抑制剂,因此可用于治疗由pi3K-δ介导的疾病,如炎症,哮喘,慢性阻塞性肺病和癌症.

专利信息

专利号:US-9192612-B2
优先权日:2013-02-13
标题:Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; BECK ELIZABETH MARY; DAVOREN JENNIFER ELIZABETH; LACHAPELLE ERIK ALPHIE; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 and R 2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.