CAS: 86933-74-6; Neurokinin A

📜在 三异丙基硅烷,三氟乙酸体系中,用 水 作为反应溶剂,化学反应 1.0H,以187 Mg的收率获得产物神经激肽a
参考文献:在无水有机溶剂中使用枯草杆菌蛋白酶a的侧链保护肽的酶片段缩合:合成工业肽的一般策略.
标题:在无水有机溶剂中使用枯草杆菌蛋白酶a的侧链保护肽的酶片段缩合:合成工业肽的一般策略.
摘要:在此,描述了在无水有机溶剂中使用枯草杆菌蛋白酶a对侧链保护的肽片段进行酶促缩合.用具有h-Xxx-Val-Nh 2亲核试剂的二肽cbz-Val-Xxx羧酰胺甲基酯进行了筛选,其中xxx代表每个(侧链保护的)氨基酸残基.最后,证明了用酶法以很高的转化率缩合带有多个侧链保护基团的较大的肽片段(至多10个聚合物的水平)是可行的.
DOI:10.1002/adsc.201200694

专利信息

专利号:US-9475814-B2
优先权日:2011-10-03
标题:Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
发明人：HOVEYDA HAMID R; DUTHEUIL GUILLAUME; FRASER GRAEME L; ROY MARIE-ODILE; EL BOUSMAQUI MOHAMED; BATT FREDERIC
权利人:EUROSCREEN SA
摘要:The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.

专利号:WO-9108220-A1
优先权日:1989-12-01
标 题:A method for the stepwise, controlled synthesis of chemical species, particularly peptides, coupled products obtained by the method and the use of these coupled products, e.g. as vaccines
发明人：HOUEN GUNNAR; HOLM ARNE
权利人:HOUEN GUNNAR; HOLM ARNE
摘要:Chemical species, particularly peptides, are synthesized by a stepwise, controlled process, in which a proteinaceous substance such as a protein is used as the synthesis substrate. The products obtained by the process can be used e.g. as vaccines against various diseases and as matrix materials or carrier molecules.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6600970-B2
优先权日:2000-09-06
标 题:Method of establishing synthesis paths
发明人：BLEY KLEMENS
权利人:MERCK PATENT GMBH
摘要:A method of establishing a synthesis path in a multiplicity of potentially interlinakable reactions, and a computer program to prepare a synthesis path.

专利号:US-2022401561-A1
优先权日:2019-09-30
标题 :Protein-macromolecule conjugates and methods of use thereof
发明人：SONG YUNTAO; LI HUI; ZHOU HAIPING; LIAO CHUAN
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that ae based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

专利号:US-6420110-B1
优先权日:1998-10-19
标 题 :Methods and reagents for isolating biologically active peptides
发明人：GYURIS JENO; MORRIS AARON J
权利人:GPC BIOTECH INC
摘要:One aspect of the present invention is the synthesis of a binary method that combines variegated peptide display libraries, e.g., in a “display modeâ€?, with soluble secreted peptide libraries, e.g., in a “secretion modeâ€?, to yield a method for the efficient isolation of peptides having a desired biological activity.