CAS: 852475-26-4; (E)-3-(5-((E)-3-(3-Fluorophenyl)-3-Oxoprop-1-En-1-yl)-1-Methyl-1H-Pyrrol-2-yl)-N-Hydroxyacrylamide

上下游产品

ethyl 3-(1-methyl-1H-pyrrol-2-yl)-2-propenoate N-methylpyrrole aldehyde ethyl (2E)-3-(1-methyl-1H-pyrrol-2-yl)prop-2-enoate

📜N-甲基-2-吡咯甲醛置于草酰氯,Potassium Tert-Butylate,1-羟基苯并三唑,对甲苯磺酸,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,三乙胺,Potassium Hydroxide体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,水,1,2-二氯乙烷 作为反应溶剂,化学反应 66.25H,反应生成 Mc 1568; 3-[4-[3-(3-氟苯基)-3-氧代-1-丙烯基]-1-甲基-1H-吡咯-2-基]-N-羟基-2-丙烯酰胺
参考文献: Compositions And Methods For Treating Epigenetic Disease[fr] Compositions Et Procédés De Traitement D'Une Maladie épigénétique
标题: Compositions And Methods For Treating Epigenetic Disease[fr] Compositions Et Procédés De Traitement D'Une Maladie épigénétique
摘要:本公开提供了能够治疗癌症或自身免疫疾病(如克罗恩病)的化合物和组合物,以及它们的使用方法.

专利信息

专利号:US-2023220001-A1
优先权日:2020-06-09
标 题:Method for synthesis of thioether-containing peptides
发明人：GRUSS HENDRIK; LUTZ CHRISTIAN; SÃœSSMUTH RODERICH; Yao guiyang; KNITTEL CAROLINE; KOSOL SIMONE; MAINZ ANDI
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present invention relates to a method of formation of a sulphur bridge between tryptophan and cysteine in solid phase peptide synthesis under iodine treatment. The invention also relates to the resulting compounds of the method and their respective use.

专利号:US-6288297-B1
优先权日:1998-10-01
标 题:Process for the preparation of cyclopropylacetylene
发明人：WANG ZHE; YIN JIANGUO; FORTUNAK JOSEPH M; CAMPAGNA SILVIO
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor. In the process, for example, cyclopropane carboxaldehyde is alkylated to form 1,1,1-trichloro-2-cyclopropyl-ethanol; which in turn is hydroxy protected to form 1,1,1-trichloro-2-cyclopropylethyltosylate; which in turn undergoes elimination to form cyclopropyl acetylene. This improvement provides for high conversion of inexpensive, readily available starting materials into cyclopropylacetylene, high overall yields and can be conducted on an industrial scale.

专利号:US-10759743-B2
优先权日:2016-10-24
标 题 :Pd-catalyzed γ-C(sp3)-H arylation / heteroarylation of free amines
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

专利号:US-8921580-B2
优先权日:2012-05-09
标 题 :Methods and systems for the formation of cyclic carbonates
发明人：HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

专利号:US-5840961-A
优先权日:1996-07-12
标 题:Asymmetric synthesis of chiral beta-amiNo acids
发明人：BEHLING JAMES RICHARD; BOYS MARK LAURENCE; CAIN-JANICKI KIMBERLY JO; COLSON PIERRE-JEAN; DOUBLEDAY WENDEL WILLIAM; DURAN JOSEPH EDWARD; FARID PAYMAN N; KNABLE CARL MATTHEW; MUELLNER FRANK WALTER; NUGENT SEAN THOMAS; TOPGI RAVINDRA S
权利人:SEARLE & CO
摘要:The invention herein is directed to a process for the preparation of ethyl 3S-amino-4-pentynoate which involves treating 3-(trimethylsilyl)-2-propynal with L-phenylglycinol in toluene to produce αS- 3-(trimethylsilyl)-2-propynylidene amino!benzenethanol; reacting αS- 3-(trimethylsilyl)-2-propynylidene!amino!benzenethanol with BrZnCH 2 CO 2 t-Bu in THF/NMP to produce 1,1-dimethylethyl 3S- (2-hydroxy-1S-phenylethyl)amino!-5-(trimethylsilyl)-4-pentynoate; reacting the 1,1-dimethylethyl 3S- (2-hydroxy-1S-phenylethyl)amino!-5-(trimethylsilyl)-4-pentynoate with sodium periodate to form 1,1-dimethylethyl 3S- (phenylmethylene)amino!-5-(trimethylsilyl)-4-pentynoate; hydrolyzing 1,1-dimethylethyl 3S- (phenylmethylene)amino!-5-(trimethylsilyl)-4-pentynoate to produce 1,1-dimethylethyl 3S-amino-5-(trimethylsilyl)-4-pentynoate; transesterifying 1,1-dimethyl 3S-amino-5-(trimethylsilyl)-4-pentynoate and desilylating to produce ethyl 3S-amino-4-pentynoate.

专利号:CN-112430236-A
优先权日:2020-11-27
标题:Synthesis of Chiral Spiro[pyrrolidone-3,3'-oxindole] Ring System and Its Application in Natural Product Synthesis