CAS: 7411-49-6; 3,3',4,4'-Biphenyltetramine Tetrahydrochloride

专利信息

专利号:US-6372721-B1
优先权日:1993-12-17
标题:Method for inducing DNA synthesis in neurons
发明人：NEUMAN TOOMAS; SUDA KIKUO; NORNES HOWARD O
权利人:SPINAL CORD SOC
摘要:A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

专利号:US-6025477-A
优先权日:1986-03-31
标题 :Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
发明人：CALENOFF EMANUEL
摘要:This invention provides purified antigens which are indicative of the presence of atherosclerotic plaque. Different concentrations of these antigens have been found to coincide with the progression of atherosclerosis. The subject invention also provides different hybridoma cell lines which produce monoclonal antibodies directed to antigens associated with atherosclerosis and a hybridoma cell line which produces monoclonal antibodies directed to antigen associated with normal artery and not with plaque. The atherosclerotic plaque antigen, and monoclonal antibodies made thereto, are used in various methods for detecting in a biological sample an antigen present in, and indicative of the presence of, atherosclerotic plaque. The monoclonal antibodies are also used in methods of imaging atherosclerotic plaque, and treating atherosclerosis. The methods of treating atherosclerosis include a method of digesting atherosclerotic plaque with enzymes, and a method of ablating atherosclerotic plaque using radiation. The subject invention also provides a method of treating atherosclerotic plaque by directly delivering a drug to the plaque. The subject invention further provides a method for treating atherosclerosis by blocking the synthesis of atherosclerotic plaque or by blocking binding of antibodies to the antigen.

专利号:US-2003224420-A1
优先权日:2002-04-05
标题 :Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
发明人：HELLERSTEIN MARC K; KIM SYLVIA JEEWON
摘要:This invention relates to a method for separating long-term label retaining cells or stem cells. In particular, this invention relates to a method for separating long-term label retaining cells and/or stem cells from tissues or individuals and for measuring proliferation rates of long-term label retaining cells and stem cells, as well as determining clonal expansion (proliferative history) of cell lineages from the tissues of the individual. The cells may be double-labeled with a cell-lineage marking label and isotopically labeled DNA synthesis precursor prior to physical separation.

专利号:WO-0010389-A1
优先权日:1998-08-18
标题 :BLOCKADE OF GLUCOSE TOXICITY TO THE β CELLS IN THE ISLETS OF LANGERHANS
发明人：KUDLOW JEFFREY E
权利人:UAB RESEARCH FOUNDATION
摘要:The present invention demonstrates that streptozotocin (STZ) is a specific toxin for the pancreatic β cells and that STZ specifically inhibits the activity of O-GlcNAc-selective N-acetyl-β-D-glucosaminidase (O-GlcNAcase), therefore, blocks O-linked N-acetylglucosamine (O-GlcNAc) removal from intracellular proteins. The present invention is also directed to a transgenic animal with impaired glucosamine synthesis and various methods of treating diabetes and of screening for drugs for treating diabetes.

专利号:US-7588757-B2
优先权日:2001-03-14
标题 :Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
发明人：OZAWA KEIYA; FUJIMOTO KEN-ICHI; MURAMATSU SHIN-ICHI; IKEGUCHI KUNIHIKO; NAKANO IMAHARU
权利人:GENZYME CORP
摘要:Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous system of a primate. Once delivered, the genes are expressed, which then results in dopamine synthesis and amelioration in the clinical signs and symptoms of PD. The methods of the present invention can be used to deliver the three central dopamine synthesizing enzymes: tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and guanosine triphosphate cyclohydrolase I thereby enhancing dopamine biosynthesis and providing for enhanced therapeutic efficacy.

专利号:US-6900191-B1
优先权日:1997-02-25
标 题 :1α-Hydroxyvitamin D5, its synthesis and use in cancer prevention
发明人：MORIARTY ROBERT M; PENMASTA RAJU A; GUO LIANG; RAO MUNAGALA S; MEHTA RAJENDRA G
权利人:ONCQUEST INC
摘要:A compound of formula I: n n nwherein R1 is hydrogen, R2 is —CH 3 , R3 is —CH 3 , and R4 is hydrogen, useful in cancer prevention and therapy.