专利号:US-5948693-A 优先权日:1994-09-01 标题:Solid phase synthesis of immunosuppressive agents 发明人:RICH DANIEL H; RAMAN PRAKASH; ANGELL YVONNE M 权利人:WISCONSIN ALUMNI RES FOUND 摘要:The present invention relates generally to cyclosporin analogs, and more paritcularly to methods for the solid-phase synthesis and on-resin cyclization of cyclosporin analogs. Methods are described for the on-resin cyclization of sterically hindered compounds synthesized through solid phase synthesis techniques. The methods utilize solvent, temperature, and washing conditions that allow the efficient on-resin cyclization of compounds like analogs of cyclosporin A.
专利号:US-4130514-A 优先权日:1978-02-10 标 题:Synthesis of peptides 发明人:ENKOJI TAKASHI; SKIBBE MARTIN O 权利人:ARMOUR PHARMA 摘要:Peptides having adrenocorticotropic hormone activity and resin peptides useful in preparation of such peptides, particularly such peptides having asparagine at the carboxyl end thereof and more particularly such peptides having from 19 to 25 amino acids in their amino acid chains. The invention further involves new processes for the preparation of such peptides.
专利号:WO-9846247-A1 优先权日:1997-04-14 标 题:Solid phase synthesis of immunosuppressive agents
专利号:WO-9604297-A1 优先权日:1994-08-02 标 题:Synthesis and use of amino acid fluorides as peptide coupling reagents
专利号:CN-105524271-A 优先权日:2014-10-24 标题 :Synthesis and Application of Cholic Acid Modified Polyamino Acid Block Copolymer
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
合成参考文献
参考文献:10.1007/s10517-015-2784-1 摘要:Kolyasnikova KN, Nazarova GA, Gudasheva TA, Voronina TA, Seredenin SB. Antihypoxic Activity of Cycloprolylglycine Analogs. Bulletin of Experimental Biology and Medicine. 2015 Feb 24;158(4):458–60. doi: 10.1007/s10517-015-2784-1.