CAS: 72291-30-6; Methyl 2-Cyano-2-Methylpropanoate

相似化合物

13051-21-3 13865-20-8 19295-57-9

上下游产品

ethyl 2-cyanoacetate methyl iodide dimethyl sulfate methyl 3-amino-2,2-dimethylpropionate aminopivalinamide 2-cyano-2-methylpropanamide 2-cyano-2-methylpropanoic acid

📜氰乙酸甲酯,碘甲烷置于caesium Carbonate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 72.0H,以11 G的收率获得产物2-氰基-2-甲基丙酸甲酯
参考文献: 4-Hydroxy-Isoquinoline Compounds As Hif Hydroxylase Inhibitors[fr] Composés 4-Hydroxy-Isoquinoléine Comme Inhibiteurs D'Hydroxylase Hif
标题: 4-Hydroxy-Isoquinoline Compounds As Hif Hydroxylase Inhibitors[fr] Composés 4-Hydroxy-Isoquinoléine Comme Inhibiteurs D'Hydroxylase Hif
摘要:本发明涉及式(I)的新化合物,以及能够选择性地抑制phd1酶活性而不影响其他同工酶(例如phd2和/或phd3酶)的组合物.该发明还涉及式(I)的化合物在肌肉退化,结肠炎,炎症性肠病和某些缺血症等疾病中的应用.

专利信息

专利号:US-2012149895-A1
优先权日:2009-04-01
标题 :Process for dimethylation of active methylene groups
发明人：JENKO BRANKO; COPAR ANTON
权利人:JENKO BRANKO; COPAR ANTON; LEK PHARMACEUTICALS
摘要:The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide can be used as intermediates in the route of synthesis of therapeutic, prophylactic or diagnostic agent, for example aliskiren or cryptophycin. Particularly, the invention relates to embodiments further extending to processes for preparing pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention can be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or crypthophycin.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-2007191395-A1
优先权日:2004-02-16
标题 :Heterocyclic compounds having antifungal activity
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
权利人:KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
摘要:A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.