CAS: 7012-37-5; 2,4,4'-Trichloro-1,1'-Biphenyl

上下游产品

4,4',6-Trichlor-2'-carboxy-biphenyl 1-Chloro-4-iodobenzene 2,4-dichloro-1-iodo-benzene 1-bromo-2,4-dichlorobenzene 4,4'-Dichlor-2-biphenylcarbonsaeure 2,4'-dichlorobiphenyl 4,4'-dichlorobiphenyl PCB 7

📜2,4,4'-Trichloro-3,3'-Bis-Trimethylsilanyl-Biphenyl置于四丁基氟化铵体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,反应生成 2,4,4'-三氯联苯
参考文献:间位而非邻位定向金属化:支撑效应妨碍从(2,6-二卤苯基)硅烷中提取质子
标题:间位而非邻位定向金属化:支撑效应妨碍从(2,6-二卤苯基)硅烷中提取质子
摘要:(2,6-二氯苯基)三甲基-和-三乙基硅烷对强碱表现出非典型的反应模式.当用 2,2,6,6-四甲基哌啶锂在-100 摄氏度下处理时,它们会产生两种,仲丁基或叔丁基锂,甚至三种不同的有机金属中间体,它们可以被标准物质截获.亲电试剂.三烷基甲硅烷基在两个方面介入.对相邻的氯原子施加空间压力,它促进其中一个原子对锂的置换置换,这是一种副反应,每当烷基锂化合物时就会发生.受雇.同时,由于空间位阻的中继传输,它阻止了紧邻卤素的碱对氢原子的攻击.作为结果,去质子化优先或仅发生在 5-(Qmetaq) 而不是 4-(Qorthoq) 位置.4-锂化物种,作为副产品或 Sep 产生.通过置换卤素/金属互变,在-75 摄氏度下消除氯化锂以释放被芳基锂前体捕获的二脱氢苯 (Qarynesq).[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200500553

专利信息

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-12404293-B2
优先权日:2019-02-28
标 题 :Method for producing glycan, building block for gylican synthesis, and compound
发明人：NOKAMI TOSHIKI; ITOH TOSHIYUKI; SAKAI HIRAKU; HAMADA TOMOAKI
权利人:NAT UNIV CORP TOTTORI UNIV; KOGANEI LTD
摘要:This invention provides a method for producing a glycan with improved yield ratio of streocontrolled glycan. Additionally it provides the building blocks used as the sugar donor and as the sugar acceptor to implement a method for producing the glycan. It also provides a novel compound. It subjects the specific building block A of this invention to electrolytic oxidation in an aprotic organic solvent that contains an electrolyte; and subjects the specific building block B of this invention to glycosylation with the electrolytically oxidized building block A in the method for producing a glycan based on the liquid phase process.