CAS: 62882-00-2; 8-Methylisoquinoline

该化合物是一种有机化合物,被归类为环环芳烃化合物,其特点是一个由苯环和环组成的引信环结构,在8位置的等离子线框架中附着一个甲基组,该化合物一般为黄色至褐色液体或固体,视其纯度和形态而定,视其在药用化学中的潜在用途而定,特别是因其生物活动而在药物开发中的潜在用途而闻名. 8-甲基乙基松碱可以表现出诸如荧光等特性,并可能参与各种化学反应,包括电子生物替代和核核生殖添加.其溶性在不同溶剂中各不相同,一般在标准条件下保持稳定.然而,与许多有机化合物一样,它应该谨慎处理,因为如果吸入或摄入,它可能会对健康造成危害.

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CAS号109245-75-2 o-methylbenzyli... | CAS号529-20-4 邻甲基苯甲醛 | CAS号54879-71-9 2,2-dimethoxy-N... | CAS号7344-34-5 4-甲基-1H-茚 | CAS号645-36-3 氨基乙醛缩二乙醇 | CAS号116409-35-9 8-methyl-2H-iso...

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    📜4-甲基-1H-茚 反应生成 8-甲基异喹啉
    参考文献:Synthesis Of Isoquinolines From Indenes
    标题:Synthesis Of Isoquinolines From Indenes
    摘要:
    DOI:10.1021/jo01314A019

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    专利信息


    专利号:US-2007275962-A1
    优先权日:2003-09-10
    标 题:Heterobicyclic Compounds as Pharmaceutically Active Agents
    发明人：KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
    权利人:GPC BIOTECH AG
    摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

    专利号:US-8754237-B2
    优先权日:2006-02-14
    标题:Bifunctional histone deacetylase inhibitors
    发明人：BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L
    权利人:BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L; HARVARD COLLEGE; DANA FARBER CANCER INST INC
    摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

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    合成参考文献


    摘要:Álvarez, M.; Joule, J. A., Science of Synthesis, (2005) 15, 706.
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