CAS: 575-04-2; 7-Methoxy-4-(Trifluoromethyl)-2H-Chromen-2-One

上下游产品

7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one methyl iodide dimethyl sulfate 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one

📜5-Methoxy-2-Trifluoroacetylphenol置于吡啶,Chromium(Vi) Oxide,Sodium Hydride体系中,用 乙醚,二氯甲烷 作为反应溶剂,化学反应 40.0H,反应生成 7-甲氧基-4-(三氟甲基)香豆素
参考文献:2-(三氟乙酰基)苯酚与乙烯基三苯基氯化鏻反应合成4-三氟甲基-2H-色烯
标题:2-(三氟乙酰基)苯酚与乙烯基三苯基氯化鏻反应合成4-三氟甲基-2H-色烯
摘要:根据 Schweizer 协议,在苯环上取代的 4-Cf 3-2 H-色烯由取代的 2-(三氟乙酰基)苯酚和乙烯基三苯基氯化鏻以中等至优异的产率制备.研究了芳环取代基的类型和位置对4-Cf 3-2 H-色烯收率的影响.已经表明4-Cf 3-2 H-色烯是4-Cf 3-香豆素的方便前体.
DOI:10.1039/d2Ob01177H

专利信息

专利号:US-11091445-B2
优先权日:2016-10-24
标题 :Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
发明人：RUCH WERNECK GUIMARÃES CRISTIANO; FELYPE ZANETI DE AZEVEDO HATYLAS; MASCARELLO ALESSANDRA; WATANABE DA COSTA RENATA; FREIRE TORRES RUSSO VALTER; MANNOCHIO DE SOUZA RUSSO ELISA
权利人:ACHE LABORATORIOS FARMACEUTICOS SA
摘要:The present disclosure relates to novel and inventive pharmacologically active benzimidazole derivative compounds, which surprisingly have high affinity for melatonin MT1 and MT2 receptors and low affinity for CYP450 complex enzymes, specially CYP1A2. The present invention also relates to novel and inventive routes of synthesis of these compounds, pharmaceutical compositions comprising the compounds and the use of these compounds in the treatment of individuals affected by psychiatric disorders and/or sleep disorders related to these receptors (specially depression, anxiety, circadian cycle disorders), in addition to a process for producing the composition.

专利号:SA-109300715-B1
优先权日:2008-12-01
标 题 :Synthesis of (R)-3-((E)-2-(pyrrolidine-3-yl)-phenyl)-5-(tetrahydropyrane-4-yloxy)pyridine and forms new salts thereof

专利号:US-8633227-B2
优先权日:2008-12-01
标 题 :Synthesis and novel salt forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine
发明人：AKIREDDY SRINIVASA RAO; BREINING SCOTT R; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; GATTO GREGORY J; GENUS JOHN; HAMMOND PHILIP S; MITCHENER JR JOESPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; YOHANNES DANIEL; FEDOROV NIKOLAI
权利人:AKIREDDY SRINIVASA RAO; BREINING SCOTT R; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; GATTO GREGORY J; GENUS JOHN; HAMMOND PHILIP S; MITCHENER JR JOESPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; YOHANNES DANIEL; FEDOROV NIKOLAI; TARGACEPT INC
摘要:The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions.

专利号:CA-2744197-A1
优先权日:2008-12-01
标 题 :Synthesis and novel salt forms of (r)-3-((e)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine

专利号:US-2012015983-A1
优先权日:2008-12-01
标 题 :Synthesis and Novel Salt Forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine

专利号:US-2014107163-A1
优先权日:2008-12-01
标题:Synthesis and novel salt forms of (r)-3-((e)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine