CAS: 57014-02-5; Eel Calcitonin

专利信息

专利号:US-5175146-A
优先权日:1989-12-05
标题 :Synthetic calcitonin peptides
发明人：BASAVA CHANNA; HOSTETLER KARL Y
权利人:VICAL INC
摘要:Synthetic hypocalcemic peptides which are similar in biological properties to native calcitonins as clinically useful agents. The peptides comprise analogues of native calcitonins having amino acid substitutions and deletions which act to improve potency, prolong duration of the hormonal effect, enhance receptor binding, and increase oral or nasal bioavailability. The calcitonin peptide analogues are less expensive and more easily synthesized than native calcitonins, and have improved resistance to inactivation or degradation. Methods are provided for the synthesis of these peptides. Also, disclosed are novel cyclic peptides, including calcitonin, having increased stability with respect to proteolysis. Methods for the synthesis of these peptides are provided, comprising converting disulfide cyclic peptides and proteins to enzymatically and chemically stable cyclic peptide structures by the replacement of cysteine residues with dicarboxylic acids and diamino acids. The method is applicable to various naturally occurring peptides, their synthetic analogues or derivatives, and proteins.

专利号:US-2010062970-A1
优先权日:2006-08-18
标题 :Synthesis of propyl phenoxy ethers and use as delivery agents

专利号:WO-2008022242-A2
优先权日:2006-08-18
标 题:Synthesis of propyl phenoxy ethers and use as delivery agents

专利号:CA-2661018-C
优先权日:2006-08-18
标题 :Synthesis of propyl phenoxy ethers and use as delivery agents

专利号:US-2005143568-A1
优先权日:2003-12-31
标 题 :Peptide synthesis using filter decanting
发明人：SCHWINDT MARK A
摘要:The invention provides methods for synthesizing peptides, which include a step of filter decanting. Filter decanting involves removing supernatant from a mixture containing a precipitated peptide. A filter decanting apparatus can be used to remove the supernatant. The invention also provides methods, such as deprotection methods, that can be performed prior to the filter decanting method.

专利号:CA-2661018-A1
优先权日:2006-08-18
标 题 :Synthesis of propyl phenoxy ethers and use as delivery agents