5-硝基-2-羟基吡啶-3-羧酸 反应生成 2-羟基-5-硝基吡啶 参考文献:The Condensation Of Sodium Nitromalonaldehyde With Cyanoacetamide1 标题:The Condensation Of Sodium Nitromalonaldehyde With Cyanoacetamide1 摘要: DOI:10.1021/ja01609A077
专利号:US-10906895-B2 优先权日:2017-02-16 标 题:Processes for the preparation of benzodiazepine derivatives 发明人:KIM IN JONG; YU JIANMING; BLAISDELL THOMAS P; Panarese Joseph; SHOOK BRIAN C; OR YAT SUN 权利人:ENANTA PHARM INC 摘要:The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): n n n n n n n n n n In particular, the present invention also relates to processes and intermediates for the preparation of compound I-a:
专利号:US-11344858-B2 优先权日:2019-05-02 标 题 :Micro-electrolysis reactor for ultra fast, oxidant free, C—C coupling reaction and synthesis of daclatasvir analogs thereof 发明人:SINGH AJAY KUMAR; PABBARAJA SRIHARI; GHOSH SUBHASH; BHUSHAN MAHAJAN; MUJAWAR TAUFIQUEAHMED 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.
专利号:US-8921573-B2 优先权日:2011-10-18 标 题:Processes for the preparation of novel benzimidazole derivatives 发明人:TANG DATONG; XU GUOYOU; PENG XIAOWEN; YING LU; WANG CE; CAO HUI; LONG JIANG; KIM IN JONG; WANG GUOQIANG; QIU YAO-LING; OR YAT SUN 权利人:ENANTA PHARM INC 摘要:The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatitis C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):
专利号:JP-2010535784-A 优先权日:2007-08-08 标 题 :Method for the synthesis of compounds useful for the treatment of hepatitis C
专利号:JP-5324574-B2 优先权日:2007-08-08 标 题:Method for the synthesis of compounds useful for the treatment of hepatitis C
专利号:US-2020346182-A1 优先权日:2019-05-02 标 题 :Micro-electrolysis reactor for ultra fast, oxidant free, c-c coupling reaction and synthesis of daclatasvir analogs thereof