CAS: 52980-68-4; (S)-2-(4-(Methylamino)Benzamido)Pentanedioic Acid
该化合物是L-甘酸的一种化学修正衍生物,其特点是甲基氨基替代苯并基组,该化合物主要用于生化研究和制药应用,因为它具有作为药物合成中间体的潜力,其结构特性使得有选择性的回活动,对于有针对性地修改浸泡物和共生化学很有价值.
- 英文名称(S)-2-(4-(Methylamino)Benzamido)Pentanedioic Acid
- 中文名称N-[4-(甲基氨基)苯甲酰基]-L-谷氨酸
- IUPAC名称(4-(methylamino)benzoyl)-L-glutamic acid
- 其它别名(2S)-2-[(4-Methylaminobenzoyl)Amino]Pentanedioic Acid; Methotrexate Ep Impurity L (N-(4-Methylaminobenzoyl)-L-Glutamic Acid); Methotrexate Ep Impurity L（amethopterin Ep Impurity L）; 2-[[4-(Methylamino)Benzoyl]Amino]Pentanedioic Acid; N-(4-(Methylamino)Benzoyl)-L-Glutamic Acid; Methotrexate Ep Impurity L; Methotrexate Impurity 12(Ep-L); Methotrexate Impurity L
- CAS编号52980-68-4
- MFCD编号:MFCD11559083
- EINECS号:610-925-7
- FDA UNII编号:G343E7DX5Q
- 分子式:C13H16N2O5分子量:280.28
- 产品CID: 2501930
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号138965-46-5 3-[3-((allyloxy... | CAS号91871-28-2 N-allyloxycarbo... | CAS号38974-68-4 N-对碘苯甲酰-L-谷氨酸 | CAS号74-89-5 氨基甲烷 | CAS号4271-30-1 N-(4-氨基甲酰)-L-谷氨酸 | CAS号59-05-2 甲氨蝶呤 | CAS号2410-93-7 氨甲叶酸杂质C | CAS号59-05-2 甲氨蝶呤合成工艺路线路线简述
📜3-[3-((Allyloxy)Carbonyl)-5-Oxo-1,3-Oxazolan-4-Yl]Propanoic Acid置于四(三苯基膦)钯 1,1,2,3-四甲基胍,Sodium,二乙胺体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 5.0H,反应生成 N-[4-(甲基氨基)苯甲酰基]-L-谷氨酸
参考文献:Efficient Syntheses Of Pyrofolic Acid And Pteroyl Azide,Reagents For The Production Of Carboxyl-Differentiated Derivatives Of Folic Acid
标题:Efficient Syntheses Of Pyrofolic Acid And Pteroyl Azide,Reagents For The Production Of Carboxyl-Differentiated Derivatives Of Folic Acid
摘要:Reaction Of Folic Acid (1) With Excess Trifluoroacetic Anhydride Provides Access To Both The Previously Unknown N-10-(Trifluoroacetyl)Pyrofolic Acid (8) And Pyrofolic Acid (9). Reaction Of Either Of These Materials With Hydrazine Selectively Affords Pteroyl Hydrazide (13),Which May Be Oxidized To Pteroyl Azide (27) On A Large Scale (62% Overall From 1 Without The Need For Chromatography). Treatment Of 27 With Differentially Protected Glutamates Provides A Convenient And High-Yielding Synthesis Of Differentially Protected,Optically Pure Folates.
DOI:10.1021/ja971568J
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛
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专利信息
专利号:US-4136101-A
优先权日:1978-02-03
标题:Process for preparing dialkyl (p-aminobenzoyl) glutamates
发明人：KAZAN JOHN
权利人:AMERICAN CYANAMID CO
摘要:A process for the preparation of dialkyl (p-aminobenzoyl) glutamates is disclosed. Dialkyl (p-Aminobenzoyl) glutamates are useful as intermediates in the synthesis of N-{p-([(2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as 4-amino-N 10 -methylpteroylglutamic acid. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate, is also disclosed.
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合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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