CAS: 5142-23-4; 3-Methyl-3H-Purin-6-Amine

上下游产品

CAS号76227-27-5 N'-benzyloxy-5-... | CAS号125661-70-3 9-Benzyl-N6-eth... | CAS号3506-01-2 Adenosine, 2'-d... | CAS号76227-20-8 (2R,3S,5R)-5-(1... | CAS号72055-63-1 3-甲基腺苷对甲苯磺酸盐 | CAS号21149-25-7 腺嘌呤-7-氧化物 | CAS号66224-66-6 6H-Purin-6-imin... | CAS号1006-11-7 3-甲基-3H- 嘌呤-6(9H)-酮

3-Benzyladenine置于镍 Sodium Hydroxide,硫酸,氢气,Magnesium Monoperoxyphthalate Hexahydrate体系中,用 甲醇,水,甲苯 作为反应溶剂,25.0~40.0 °C,101.33 Kpa 条件下,反应 30.0H,反应生成 6-氨基-3-甲基嘌呤
参考文献:Fujii,Tozo; Ogawa,Kazuo; Saito,Tohru,Heterocycles,1994,Vol. 38,# 3,P. 477-480
标题:Fujii,Tozo; Ogawa,Kazuo; Saito,Tohru,Heterocycles,1994,Vol. 38,# 3,P. 477-480

专利信息

专利号:US-12421628-B2
优先权日:2018-07-23
标题:Massively parallel enzymatic synthesis of nucleic acid strands
发明人：HORGAN ADRIAN; GODRON XAVIER; YBERT THOMAS; NICOL ROBERT
权利人:DNA SCRIPT
摘要:The invention is directed to methods for massively parallel template-free enzymatic synthesis of a plurality of different polynucleotides of predetermined sequences. In one aspect, methods of the invention employ large scale arrays of reaction sites each associated with at least one working electrode for controlling deprotection and deblocking steps at predetermined user selected sites. In another aspect, the invention provides template-free enzymatic synthesis with proofreading, wherein completed polynucleotides at predetermined reaction sites are sequenced using a sequencing by synthesis technique, particularly employing electrochemically labile blocking groups.

专利号:US-2024052391-A1
优先权日:2020-10-29
标 题 :Enzymatic Synthesis of Polynucleotide Probes
发明人：GODRON XAVIER; NIYOMCHON SUPAPORN; CHAMPION ELISE
权利人:DNA SCRIPT
摘要:The present invention is directed to methods and kits for enzymatic synthesis of labeled polynucleotide probes using template-free DNA polymerases.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2024384319-A1
优先权日:2021-09-17
标题 :Synthesis of Oligonucleotides
发明人：LOVELOCK SARAH
权利人:UNIV MANCHESTER
摘要:The present invention relates to a novel method for oligonucleotide synthesis, using a catalytic primer-template, e.g. a hairpin primer, to achieve multiple rounds of oligonucleotide synthesis and dissociation from the template in the same reaction, such that at the end of the reaction the amount of oligonucleotide generated is greater than the amount of template provided in the reaction. The primer contains a cleavable site and the reaction is carried out in a single mixture with a cleavage agent. The cleavable site may be an inosine and the agent an endonuclease V.

专利号:US-2006194214-A1
优先权日:2005-02-28
标题 :Methods for assembly of high fidelity synthetic polynucleotides
发明人：CHURCH GEORGE; JACOBSON JOSEPH; BAYNES BRIAN M
权利人:CHURCH GEORGE; JACOBSON JOSEPH; BAYNES BRIAN M
摘要:Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of polynucleotide polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one or more oligonucleotides using “universalâ€? primers, reduction of the error rate in oligonucleotide and/or polynucleotide products, and sequence optimization and oligonucleotides design.