CAS: 50-39-5; Protheobromine

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CAS号10244-22-1 3,7-Dimethyl-1-... | CAS号83-67-0 可可碱 | CAS号75-56-9 环氧丙烷 | CAS号2530-99-6 1-Allyltheobromine | CAS号108-32-7 碳酸丙烯酯

📜3,7-Dimethyl-1-(2-Oxopropyl)Xanthine置于sodium Tetrahydroborate体系中,用 甲醇,乙醚 作为反应溶剂,化学反应生成 氟氯西林
参考文献:Potentiation Of Cadpr-Induced Ca2+-Release By Methylxanthine Analogues
标题:Potentiation Of Cadpr-Induced Ca2+-Release By Methylxanthine Analogues
摘要:Caffeine And Other Methylxanthines Are Known To Induce Ca2+-Release From Intracellular Stores Via The Ryanodine Receptor. In The Present Work,A Range Of Caffeine Analogues,In Which Methyl Groups At The 1 And 7 Positions Were Replaced With Alkyl Chains Containing Different Functional Groups (Oxo,Hydroxyl,Propargyl,Ester,And Acids),Were Synthesized. These Compounds Were Then Screened For Their Ability To Potentiate Ca2+-Release Induced By Cadpr (An Endogenous Modulator Of Ryanodine Receptors) In Sea Urchin Egg Homogenates. Two Of The Synthesized Methylxanthines,1,3-Dimethyl-7-(7-Hydroxyoctyl)Xanthine (37) And 3-Methyl-7-(7-Oxooctyl)-1-Propargylxanthine (66),Were Shown To Be More Potent Than Caffeine In Potentiating Cadpr-Induced Ca2+-Release,While 1,3-Dimethyl-7-(5-Ethylcarboxypentyl)Xanthine (14) Was Shown To Be More Efficacious. The Development Of New Methylxanthine Analogues May Lead To A Better Understanding Of Ryanodine Receptor Function And Could Possibly Provide Novel Therapeutic Agents.
DOI:10.1021/jm980469T

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications