CAS: 481-46-9; Ginkgetin

该化合物是一种主要来自Ginkgo biloba树的裂谷类化合物,以其潜在的健康惠益和抗氧化性特性而著称,它属于二氟氯素,其特征为存在两个氟化素单位. Ginkgetin 展示了一系列生物活动,包括抗炎,...

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CAS号3754-52-7 3'-iodo-5,7,4'-... | CAS号7507-89-3 1-(2,6-二羟基-4-甲氧... | CAS号99-93-4 对羟基苯乙酮

合成工艺路线路线简述

    3'-Jod-4',5,7-Trimethoxy-Flavon置于四(三苯基膦)钯 三氯化硼,Potassium Carbonate体系中,用 1,4-二氧六环,二氯甲烷,水 作为反应溶剂,化学反应 5.0H,反应生成 银杏素
    参考文献:A New Strategy For The Synthesis Of Biflavonoids Via Arylboronic Acids.
    标题:A New Strategy For The Synthesis Of Biflavonoids Via Arylboronic Acids.
    摘要:Amentoflavone Derivatives Were Prepared By Catalytic Coupling Of 8-Flavoneboronic Acids With Iodoflavones. 3-Arylflavones,As Biflavonoid Synthon,Are Accessible By The Method.
    DOI:10.1016/s0040-4039(00)79688-2

    海关参考信息

    专利信息


    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:CN-112079911-A
    优先权日:2020-09-04
    标 题:Key gene GbMYB6 for promoting synthesis of ginkgo flavonoids, and protein, vector and application of key gene GbMYB6 for expression

    专利号:CN-114480448-B
    优先权日:2022-03-11
    标题 :Gene GbF3' H for promoting synthesis of ginkgo flavonol glycosides, and vector, protein and application thereof

    专利号:CN-114480429-B
    优先权日:2022-03-11
    标题:A key gene GbDAL1 that inhibits the synthesis of ginkgo flavonol glycosides and its application

    专利号:CN-114480429-A
    优先权日:2022-03-11
    标 题 :A key gene GbDAL1 inhibiting the synthesis of ginkgo flavonol glycosides and its application

    专利号:CN-114480448-A
    优先权日:2022-03-11
    标 题:Gene GbF3' H for promoting synthesis of ginkgetin glucoside, and carrier, protein and application thereof
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    主要参考文献

    1. Y. Su, C. M. Sun, H. H. Chuang, et al. Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell line. Naunyn Schmiedebergs Arch. Pharmacol. 362(10), 82-90 (2000). 2. H. Lim, K. H. Son, H. W. Chang, et al. Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol. Pharm. Bull. 29(5), 1046-1049 (2006). 3. N. Lian, J. Tong, W. Li, et al. Ginkgetin ameliorates experimental atherosclerosis in rats. Biomed. Pharmacother. 102, 510-516 (2018). 4. Y. Q. Wang, M. Y. Wang, X. R. Fu, et al. Neuroprotective effects of ginkgetin against neuroinjury in Parkinson’s disease model induced by MPTP via chelating iron. Free Radic Res. 49(9), 1069-1080 (2015).

    合成参考文献


    参考文献:10.1055/s-2006-960815
    摘要:Kim HK, Son KH, Chang HW, Kang SS, Kim HP. Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves. Planta Med. 1999 Jun;65(5):465–7. doi: 10.1055/s-2006-960815.
    参考文献:10.1007/s12272-001-1143-0
    摘要:Moon TC, Jin M, Son JK, Chang HW. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210–5. doi: 10.1007/s12272-001-1143-0.
    参考文献:10.1111/jam.14365
    摘要:Li G, Wang G, Wang S, Deng Y. Ginkgetin in vitro and in vivo reduces Streptococcus suis virulence by inhibiting suilysin activity. J Appl Microbiol. 2019 Nov;127(5):1556–63. doi: 10.1111/jam.14365.
    参考文献:10.1002/jcb.29169
    摘要:Tian Z, Tang C, Wang Z. Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation. J Cell Biochem. 2019 Oct;120(10):18487–95. doi: 10.1002/jcb.29169.
    参考文献:10.1016/j.fct.2020.111642
    摘要:Adnan M, Rasul A, Hussain G, Shah MA, Zahoor MK, Anwar H, Sarfraz I, Riaz A, Manzoor M, Adem Ş, Selamoglu Z. Ginkgetin: A natural biflavone with versatile pharmacological activities. Food Chem Toxicol. 2020 Nov;145():111642. doi: 10.1016/j.fct.2020.111642.
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