CAS: 3736-36-5; Endo-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl 2-Hydroxy-2,2-Diphenylacetate

该化合物是属于磺酰胺一类的化学化合物,主要用于管理2型糖尿病,它作为口服低血糖剂,促进胰腺的胰岛素分泌,提高外围组织对胰岛素的敏感性.该化合物一般在水中表现出中等溶解性,其特点是其有效降低血糖水平的能力.其行动机制涉及对胰腺乙型细胞的特定受体具有约束力,导致因葡萄糖而增加的胰岛素释放.此外,与其它胰岛素相比,Glipin在造成低血糖低的潜在潜力,使其在某些病人群体中成为首选.与任何药物一样,在开药时必须考虑潜在的副作用,与其他药物的相互作用以及抗药性.总是向保健专业人员咨询个性化医疗咨询和治疗选项.

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      专利信息


      专利号:US-5900227-A
      优先权日:1996-06-17
      标题 :Multicyclic nitrone spin trapping compositions
      发明人:JANZEN EDWARD G; SANKURATRI NAGARAJU
      权利人:OKLAHOMA MED RES FOUND
      摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.

      专利号:US-5614629-A
      优先权日:1995-01-30
      标 题:Benzyl quaternary tropinium compound
      发明人:VALYOCSIK ERNEST W
      权利人:MOBIL OIL CORP
      摘要:This invention is directed to novel benzyl quaternary ammonium compounds and their synthesis. The compounds have valuable utility as organic directing agents in the crystallization of a silicate structure which, in turn, is useful as a catalyst component, sorbent, and/or ion-exchanger. More particularly, this invention is concerned with benzyl quaternary ammonium compounds synthesized by selective alkylation of the bridgehead nitrogen of tropane or quinuclidine with a benzyl salt.

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