CAS: 33577-16-1; Methyl((Methylsulfinyl)Methyl)Sulfane

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CAS号1618-26-4 二甲硫基甲烷 | CAS号21128-88-1 chloro(methylsu... | CAS号5188-07-8 甲硫醇钠 | CAS号30830-27-4 3-(苄氧基)环丁酮 | CAS号462-18-0 7-十三酮 | CAS号20163-71-7 (METHYLSULFONYL... | CAS号22906-17-8 2-(methylsulfan... | CAS号24396-27-8 2-(bis(methylth... | CAS号90-02-8 水杨醛 | CAS号19781-72-7 11-二十一酮 | CAS号1066-40-6 三甲基硅醇 | CAS号624-92-0 二甲基二硫醚 | CAS号107-46-0 六甲基二硅氧烷

📜二甲硫基甲烷置于双氧水,溶剂黄146体系中,化学反应 0.5H,反应生成甲基甲基硫代甲砜
参考文献:Dithia 化合物的氧化:1,3-双(甲硫基)丙烷,双(甲硫基)甲烷和内消旋 4,6-二甲基-1,3-二噻烷的比较实验和理论研究
标题:Dithia 化合物的氧化:1,3-双(甲硫基)丙烷,双(甲硫基)甲烷和内消旋 4,6-二甲基-1,3-二噻烷的比较实验和理论研究
摘要:1,3-二硫杂化合物中硫基的相互影响在构象受限的1,3-二噻烷中尤为明显.通过核磁共振光谱分析和使用量子化学方法计算激活势垒和立体电子效应,对不同氧化剂的氧化进行了实验研究.
Doi:10.1002/ejoc.202100940

专利信息

专利号:US-2024294462-A1
优先权日:2023-02-15
标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate
发明人：SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD
权利人:NANOVATION THERAPEUTICS INC
摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.

专利号:US-4424159-A
优先权日:1978-05-26
标 题:Process for the synthesis of the hydroxyacetyl side-chain of steroids of the pregnane type, novel 21-hydroxy-20-oxo-17α-pregnane compounds and pharmaceutical preparations containing them
发明人：BIOLLAZ MICHEL
权利人:CIBA GEIGY CORP
摘要:The present invention relates to a novel general process for synthesizing a α- or β-oriented hydroxyacetyl side chain of steroids of the pregnane type, which comprises treating a corresponding steroid carbaldehyde in succession with formaldehyde dimethylmercaptal-S-oxide in the form of an alkali metal salt thereof, and with a strongly acid hydrolysing agent. n Preferred final products are compounds of the formula ##STR1## wherein n is 1 or 2, R 2 represents methyl or difluoromethyl, and R 1 represents hydroxymethyl, methoxymethyl, acetoxymethyl or hydrogen, and, if n is 2 and/or R 2 is difluoromethyl, R 1 also represents methyl. These compounds act as agonists or antagonists of natural steroid hormones. The antigestagenic 19,21-dihydroxy-17α-pregn-4-ene-3,20-dione and its 6,7-dehydro derivatives and diacetates are of particular interest.

专利号:US-4221915-A
优先权日:1977-03-11
标题:Process for preparing thiophene derivatives and thiophene derivatives obtained thereby
发明人：KONDO KIYOSHI; TSUNEMOTO DAIEI; FUJISAWA TAMOTSU
权利人:SAGAMI CHEM RES
摘要:Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted thiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. Novel compounds, i.e. α-arylthio-2-thiopheneacetic acids are also disclosed. These compounds are useful as the intermediates of the synthesis of 2-thiopheneacetic acids.

专利号:US-4742052-A
优先权日:1981-07-15
标题:Antibacterial β-lactam compounds
发明人：SUNAGAWA MAKOTO; MATSUMURA HARUKI; INOUE TAKAAKI; ENOMOTO MASAO
权利人:SUMITOMO PHARMA
摘要:Novel beta -lactam compounds classified into penem compounds, a process for preparing the same and use of such beta -lactam compounds are disclosed. These beta -lactam compounds exhibit excellent antimicrobial activities useful as pharmaceuticals or they are important intermediates for the synthesis of compounds having antimicrobial activities.

专利号:US-5659021-A
优先权日:1987-03-13
标 题 :Chiral glycerol derivatives
发明人：ABUSHANAB ELIE
权利人:RHODE ISLAND EDUCATION
摘要:Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.

专利号:CA-2615490-A1
优先权日:2005-07-18
标题:Stereoselective synthesis of 3,4-disubstituted cyclopentanones and related compounds