CAS: 20086-06-0; (2R,3As,6S,6As,7R,10R,11Ar,11Bs)-2-(Furan-3-yl)-11B-Methyloctahydro-4H-3A,6:7,10-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepine-4,8(6H)-Dione

该化合物是一种主要与用于传统医学的植物Dioscorea bludeifera(Dioscoria bludeifera)隔离的呋喃和二二二双乳内酯化合物,它有显著的生物活动,包括潜在的抗沙尘,抗炎和肝中毒特性,使它成为药理研究感兴趣的对象.该化合物的独特结构允许与细胞目标有选择地互动,特别是在肝癌和免疫调控的研究中.它的行动机制包括抑制关键的信号路径,如NF-B和MAPK, 从而造成其细胞毒性效应.Diosbulbin B在研究环境中被利用,因为它能够诱发流行性硬化症和调节氧化压力,为治疗应用提供洞察力.高纯度的分离物可供实验使用.

英文名称(2R,3As,6S,6As,7R,10R,11Ar,11Bs)-2-(Furan-3-yl)-11B-Methyloctahydro-4H-3A,6:7,10-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepine-4,8(6H)-Dione
中文名称黄独素B
IUPAC名称(2R,3aS,6S,6aS,7R,10R,11aR,11bS)-2-(furan-3-yl)-11b-methyloctahydro-4H-3a,6:7,10-dimethanofuro[2,3-c]oxepino[4,5-e]oxepine-4,8(6H)-dione
其它别名Diosbulbin B; (2R)-2-(3-Furyl)-1,2,6Aβ,7,10,11,11Aα,11B-Octahydro-11Bβ-Methyl-4H-3Aβ,6β:7β,10β-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepine-4,8(6H)-Dione; Oroxylin A-7-Glucoronide; (2R,3As,6S,6As,7R,10R,11Ar,11Bs)-2-(3-Furanyl)Octahydro-11B-Methyl-4H-3A,6:7,10-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepin-4,8(6H)-Dione; 4H-3A,6:7,10-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepin-4,8(6H)-Dione, 2-(3-Furanyl)Octahydro-11B-Methyl-, (2R,3As,6S,6As,7R,10R,11Ar,11Bs)-; (2R,6S,6As,7R,10R,11Ar,11Bs)-2-(Furan-3-yl)-11B-Methyloctahy...; (2R,6S,6As,7R,10R,11Ar,11Bs)-2-(Furan-3-yl)-11B-Methyloctahydro-3A,6:7,10-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepine-4,8(6H)-Dione; (2R,3As,6S,6As,7R,10R,11Ar,11Bs)-2-(Furan-3-yl)-11B-Methyloctahydro-4H-3A,6:7,10-Dimethanofuro[2,3-C]Oxepino[4,5-E]Oxepine-4,8(6H)-Dione
CAS编号20086-06-0
MFCD编号:MFCD16660673
分子式:C19H20O6分子量:344.36
产品CID: 1021386
产品分类天然产物 → 萜类

相似结构搜索
InChIKey: QEANLIISUSNNDX-XBHMPIGQSA-N
InChI=1S/C19H20O6/c1-18-6-13(9-2-3-22-8-9)25-19(18)7-14(24-17(19)21)15-11-4-10(5-12(15)18)23-16(11)20/h2-3,8,10-15H,4-7H2,1H3/t10-,11+,12+,13+,14-,15+,18-,19+/m0/s1
计算化学: 氢键受体数6.0氢键供体数*可旋转键数1.0

物理性质

熔点285 °C
沸点574.8±50.0 °C at 760 mmHg
闪点301.4±30.1 °C
密度1.4±0.1 g/cm3
PSA:74.97
LogP:-0.41
折射率1.613
蒸汽压0.0±1.6 mmHg at 25°C
溶解性DMSO: 16 mg/mL (46.46 Mm; Need Ultrasonic)
外观形态白色至类白色粉末
储存条件2-8°C
产品应用该化合物用于内容确定/鉴定/药物实验等.

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319-H227
防范说明P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

合成工艺路线路线简述

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献

参考文献:10.1631/jzus.b1300250
摘要:Wang J, Sheng Y, Ji L, Wang Z. Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo. Journal of Zhejiang University-SCIENCE B. 2014 Jun 01;15(6):540–7. doi: 10.1631/jzus.b1300250.