CAS: 183321-84-8; 2,2'-((4-((3-Ethynylphenyl)Amino)Quinazoline-6,7-Diyl)Bis(Oxy))Diethanol
该化合物是一种合成有机化合物,其特征是复杂的分子结构,包括一个五氯硝基和苯乙烯基组.该化合物具有多种功能组,包括醚和酒精功能,有助于其溶解性和再活动.该化合物的存在表明有可能进一步进行化学改变或反应,从而引起对药用化学和物质科学的兴趣.该化合物的quinazoline modity往往与生物活动有关,特别是在针对各种疾病的药品研制过程中.该化合物的特性,如熔点,溶解性和稳定性,通常受其分子相互作用以及极地和非极地区域在其结构内的存在的影响.
- 英文名称2,2'-((4-((3-Ethynylphenyl)Amino)Quinazoline-6,7-Diyl)Bis(Oxy))Diethanol
- 中文名称4-[(3-乙炔基苯基)氨基]-6,7-双(2-羟基乙氧基)]喹唑啉
- IUPAC名称2,2'-((4-((3-ethynylphenyl)amino)quinazoline-6,7-diyl)bis(oxy))bis(ethan-1-ol)
- 其它别名Dimethyl Erlotinib; 2-[[4-(3-Ethynylanilino)-7-(2-Hydroxyethoxy)-6-Quinazolinyl]Oxy]Ethanol; Erlotinib Metabolite M12; O-Desmethyl Erlotinib-D8 Hcl; 4-[(3-Ethynylphenyl)Amino]-6,7-Bis(2-Hydroxyethoxy)Quinazoline; Erltinib; 2,2,-((4-((3-Ethynylphenyl)Amino)Quinazoline-6,7-Diyl)Bis(Oxy))Diethanol; Erlotinib Impurity I
- CAS编号183321-84-8
- MFCD编号:MFCD13250114
- FDA UNII编号:92T0F45VE1
- 分子式:C20H19N3O4分子量:365.39
- 产品CID: 942648
- 产品分类原料药 → 抗肿瘤药 → 替尼类抗肿瘤药
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜6,7-二羟基喹唑啉-4(3H)-酮置于吡啶,Ammonium Hydroxide,Potassium Carbonate,Potassium Iodide,三氯氧磷体系中,用 甲醇,氯仿,N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应 20.0H,反应生成4-[(3-乙炔基苯基)氨基]-6,7-双(2-羟基乙氧基)]喹唑啉
参考文献:Coupling Compounds Of Nsaid Anti-Inflammatory And Analgesic Drugs And Egfr Kinase Inhibitors,Synthesis Methods And Applications Thereof
标题:Coupling Compounds Of Nsaid Anti-Inflammatory And Analgesic Drugs And Egfr Kinase Inhibitors,Synthesis Methods And Applications Thereof
摘要:本发明揭示了一种结构如公式i,Ii或iii所示的偶联化合物,通过酯键或药用可接受的盐或其立体异构体或其前药分子连接非甾体类抗炎镇痛药和egfr抑制剂而形成:其中r为非甾体类抗炎镇痛药.在本发明中,通过将非甾体类抗炎镇痛药与egfr抑制剂偶联而获得的偶联化合物具有出色的肿瘤治疗效果,并为临床治疗提供了新的药物选择.
海关参考信息
- 2901292000-乙炔
2902300000-甲苯
2905310000-1,2-乙二醇
2907210001-间苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9452220-B2
优先权日:2014-12-23
标 题 :Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof
发明人：ZHANG YANMEI; DING KE; LIAO JINXI; WANG YICAN; CHEN PANYU
权利人:GUANGZHOU INST BIOMED & HEALTH
摘要:The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof: n n n n n n n n n n n n where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.
专利号:US-2016175453-A1
优先权日:2014-12-23
标题 :Coupling compounds of nsaid anti-inflammatory and analgesic drugs and egfr kinase inhibitors, synthesis methods and applications thereof
