CAS: 151213-42-2; (4Ar,7Ar)-Octahydro-1H-Pyrrolo[3,4-B]Pyridine

上下游产品

CAS号151213-43-3 (4aR,7aR)-八氢-6-... | CAS号1038923-76-0 (R,R)-6-(toluen... | CAS号1257241-37-4 6-(2,4-dimethox...

(4Ar,7Ar)-八氢-6-(苯甲基)-1H-吡咯并[3,4-B]吡啶置于palladium On Activated Charcoal,氢气体系中,用 甲醇 用作溶剂,化学反应生成(S,S)-2,8-二氮杂双环[4,3,0]壬烷
参考文献:(1R,6S)-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷的外消旋作用
标题:(1R,6S)-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷的外消旋作用
摘要:以碱为基础,进行了一种简单,快速,高效和环保的方法,用于在各种卤代溶剂中外消旋(1R,6S)-8苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷.催化反应以在40oc或低于40oc的温度下以优异的收率(80-95%)提供外消旋混合物.在卤化溶剂中进行碱催化的消旋反应具有操作简便的优点,并且无论类型如何,使用的卤化溶剂体积均较小反应体系中使用的溶剂.
Doi:10.13005/ojc/290138

专利信息

专利号:US-8680276-B2
优先权日:2009-03-06
标题 :Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine
发明人：MOTTERLE RICCARDO; ARVOTTI GIANCARLO; BERGANTINO ELISABETTA; CASTELLIN ANDREA; FOGAL STEFANO; GALVAGNI MARCO
权利人:MOTTERLE RICCARDO; ARVOTTI GIANCARLO; BERGANTINO ELISABETTA; CASTELLIN ANDREA; FOGAL STEFANO; GALVAGNI MARCO
摘要:The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.

专利号:CN-115073452-A
优先权日:2022-06-11
标 题:A method for continuous synthesis of moxifloxacin side chain intermediates by heterogeneous hydrogenation in a microreactor

专利号:US-2011137036-A1
优先权日:2009-03-06
标题 :SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLO[3,4-b]PYRIDINE

专利号:WO-2010100215-A1
优先权日:2009-03-06
标题:SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLO[3,4-b]PYRIDINE

专利号:EP-2403831-B1
优先权日:2009-03-06
标题 :SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLOÃ?3,4-b¨PYRIDINE

专利号:EP-2403831-A1
优先权日:2009-03-06
标 题 :SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLOÃ?3,4-b¨PYRIDINE