CAS: 13349-82-1; 2-(2-(Piperazin-1-yl)Ethoxy)Ethanol

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CAS号111-42-2 二乙醇胺 | CAS号929-06-6 二甘醇胺 | CAS号120-43-4 N-哌嗪甲酸乙酯 | CAS号628-89-7 2-(2-氯乙氧基)乙醇 | CAS号67-63-0 异丙醇 | CAS号111974-69-7 喹硫平 | CAS号848814-26-6 [4-[2-(2-hydrox...

在 Dipotassium Peroxodisulfate体系中,化学反应 6.0H,以80.5%的收率获得1-[2-(2-羟基乙氧基)乙基]哌嗪
参考文献:一种1-[2-(2-羟基乙氧基)乙基]哌嗪的制备方法
标题:一种1-[2-(2-羟基乙氧基)乙基]哌嗪的制备方法
摘要:本发明公开了有机化工材料合成技术领域内的一种1‑[2‑(2‑羟基乙氧基)乙基]哌嗪的制备方法,其以1,1'‑亚甲硫基双哌嗪和氯代二甘醇为起始原料,碳酸钠为缚酸剂,在溶剂中经缩合反应制备中间体;再加入氧化剂,经裂解反应制备1‑[2‑(2‑羟基乙氧基)乙基]哌嗪.本发明反应步骤简短,反应条件温和,产品收率高,为1‑[2‑(2‑羟基乙氧基)乙基]哌嗪的制备提供了一种新方法.本发明的目标产物在化学制药,有机合成等方面具有巨大应用价值.

专利信息

专利号:US-8389716-B2
优先权日:2009-01-30
标题:Process for the synthesis of quetiapine
发明人：SERAFINI SIRO; TOMASI FILIPPO; GALVAGNI MARCO
权利人:SERAFINI SIRO; TOMASI FILIPPO; GALVAGNI MARCO; ITALIANA SINT SPA
摘要:The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.

专利号:WO-2008152434-A1
优先权日:2007-06-12
标 题 :Synthesis for the preparation of quetiapine
发明人：CZIBULA LASZLO; DOBAY LASZLO; FEHER KRISZTINA; WERKNE PAPP EVA
权利人:RICHTER GEDEON NYRT; CZIBULA LASZLO; DOBAY LASZLO; FEHER KRISZTINA; WERKNE PAPP EVA
摘要:Process for the synthesis of 2-[2-(4-dibenzo[b,f][1,4]thiazepine-11-yl-piperazine-1-yl)-ethoxy]-ethanol of formula (I) (quetiapine) by reacting the 1-oxodibenzo-[b,f][1,4]thiazepine of formula (II) with phosphorus oxychloride by d) using 1-6 molequivalent of phosphorus oxychloride in an inert solvent and the obtained 11-chlorodibenzo[b,f][1,4]thiazepine compound of formula (IV) without isolation; e) is reacted further in an inert solvent in the presence of a base with 2-[2-(1-piperazinyl)-ethoxy]-ethanol dihydrochloride of formula (III a) or dihydrochloride monohydrate of formula (III b), in the mixture of an inert non-polar and dipolar aprotic solvent; f) in desired case the isolated quetiapine base of formula (I) is reacted with fumaric acid to form the hemifumarate salt thereof.

专利号:US-9304126-B2
优先权日:2012-08-21
标题:Haptens of quetiapine
发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

专利号:EP-0844261-A1
优先权日:1996-11-21
标题:Dispersions containing polyurethanes with carbonyl groups in ketone function
发明人：KOKEL NICOLAS DR; GULBINS ERICH DR; RAU MARIA GYOPAR DR; FISCHER GERHARD
权利人:BASF AG
摘要:R 1 , R 2 , R 3 jeweils Wasserstoff, C 1 - bis C 24 -Alkyl oder C 6 - bisnC 24 -Alkenyl R 4 Wasserstoff R 5 , R 6 a) gemeinsam C 4 - bis C 10 -Alkandiyl, b) jeweils C 2 - bis C 10 -Alkyl, C 5 - bis C 8 -Cycloalkylnoder C 7 - bis C 20 -Aralkyl, c) jeweils ein hydroxylterminiertes Poly-(C 2 - bisnC 4 -alkylenoxid), oder d) ein Rest R 5 oder R 6 die unter (a) bis (c) angegebenenBedeutung und der andere Rest Wasserstoffnoder ein Rest der Formel IIn nin der X C 2 - bis C 6 -Alkandiyl bedeutet und R 7 gleichbedeutend ist mit R 5 oder R 6 mit der Ausnahme,ndaß R 7 nicht ein Rest der Formel II bedeutet, nwobei n die Reste R 5 und R 6 in jedem der Fälle (a) bis (d) insgesamtneine (1) an ein aliphatisches C-Atom gebundene Hydroxylgruppenntragen, gegebenenfalls der Rest R 5 und/oder R 6 1 oder 2 aromatischngebundene Hydroxylgruppen oder 1 Nitril-, tertiäre Amino-,nCarbonsäure- oder Sulfonsäuregruppe, die gegebenenfalls innForm ihrer Salze vorliegen, trägt, und die mittlere Funktionalität (F) aller Aufbaukomponenten desnPolyurethans (A), bezogen auf die Funktionalitäten, die beimnAufbau des Polyurethans (A) in einer Additionsreaktion miteinandernreagieren, 1,5 bis 2,2 beträgt. Aqueous dispersions containing a polyurethane (A) with structural units which differ from compounds of the formula (I) in which the substituents have the following meaning: R 1 , R 2 , R 3 in each case hydrogen, C 1 - to C 24 -alkyl or C 6 - to C 24 -alkenyl R 4 hydrogen R 5 , R 6 a) together C 4 - to C 10 -alkanediyl, b) in each case C 2 to C 10 alkyl, C 5 to C 8 cycloalkyl or C 7 to C 20 aralkyl, c) in each case a hydroxyl-terminated poly (C 2 - to C 4 -alkylene oxide), or d) a radical R 5 or R 6 has the meaning given under (a) to (c) and the other radical is hydrogen or a radical of the formula II in the X C 2 - to C 6 -alkanediyl means and R 7 is equivalent to R 5 or R 6 with the exception that R 7 does not represent a radical of the formula II, in which the radicals R 5 and R 6 in each of cases (a) to (d) carry a total of one (1) hydroxyl groups bonded to an aliphatic carbon atom, optionally the radical R 5 and / or R 6 carries 1 or 2 aromatically bound hydroxyl groups or 1 nitrile, tertiary amino, carboxylic acid or sulfonic acid group, which are optionally present in the form of their salts, and the average functionality (F) of all structural components of the polyurethane (A), based on the functionalities which react with one another during the synthesis of the polyurethane (A) in an addition reaction, is 1.5 to 2.2.

专利号:US-8053165-B2
优先权日:2008-03-18
标 题:Hydroxyl-containing monomer, polymer, resist composition, and patterning process
发明人：KINSHO TAKESHI; OHASHI MASAKI; HASEGAWA KOJI; WATANABE TAKERU
权利人:SHINETSU CHEMICAL CO
摘要:A hydroxyl-containing monomer of formula (1) is provided wherein R 1 is H, F, methyl or trifluoromethyl, R 2 and R 3 are monovalent C 1 -C 15 hydrocarbon groups, or R 2 and R 3 may form an aliphatic ring. The monomers are useful for the synthesis of polymers which have high transparency to radiation of up to 500 nm and the effect of controlling acid diffusion so that the polymers may be used as a base resin to formulate radiation-sensitive resist compositions having a high resolution.

专利号:US-2011118460-A1
优先权日:2009-01-30
标 题:Process for the synthesis of quetiapine